Turbidimetric determination of metoclopramide hydrochloride in pharmaceutical preparation via the use of a new homemade Ayah 6SX1-T-2D Solar cell-continuous flow injection analyser
Other Title(s)
التقدير التعكري لميتاكلويراميد هايدروكلوريد في المستحضرات الصيدلانية من خلال استخدام محلل جديد مصنع محليا للحقن الجرياني المستمر Ayah 6SX1-T-2D
Joint Authors
al-Awdi, Naghm Shakir Turki
al-Saidi, Kafah Hasan Ismail
Source
Issue
Vol. 56, Issue 2B (30 Jun. 2015), pp.1224-1240, 17 p.
Publisher
University of Baghdad College of Science
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
17
Main Subjects
Abstract EN
A newly developed analytical method characterized by its speed and sensitivity for the determination of metoclopramide hydrochloride (MCP-HCl) in pure and pharmaceutical preparation via turbidimetric measurement (0-180o) by Ayah 6SX1-T-2D Solar cell-CFI Analyser.
The method was based on the reaction of phosphomolybdic acid with metoclopramide hydrochloride in acidic medium to form yellowish white precipitate for the ion-pair complex.
Turbidity was measured via the reflection of incident light that collides on the surface precipitated particles at 0-180o.
Chemical and physical parameters were studied and optimized.
The calibration graph was linear in the range of 0.0005-3 or 0.0005- 4 mMol.L-1, with correlation coefficient r = 0.9947&0.9845 respectively.
The limit of detection 3.543 ng/sample from the step wise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph with RSD % lower than 0.3 % for 1, 3 mMol.L-1 (n = 8) concentration of metoclopramide hydrochloride .
The method was successfully applied to the determination of metoclopramide hydrochloride in three pharmaceutical drugs.
A comparison was made between the newly developed method analysis with the classical method (HANNA instrument for turbidity measurement) using the standard addition method via the use of t-test.
It was noticed that there was no significant difference between two methods at 95 % confidence level.
American Psychological Association (APA)
al-Awdi, Naghm Shakir Turki& al-Saidi, Kafah Hasan Ismail. 2015. Turbidimetric determination of metoclopramide hydrochloride in pharmaceutical preparation via the use of a new homemade Ayah 6SX1-T-2D Solar cell-continuous flow injection analyser. Iraqi Journal of Science،Vol. 56, no. 2B, pp.1224-1240.
https://search.emarefa.net/detail/BIM-596699
Modern Language Association (MLA)
al-Awdi, Naghm Shakir Turki& al-Saidi, Kafah Hasan Ismail. Turbidimetric determination of metoclopramide hydrochloride in pharmaceutical preparation via the use of a new homemade Ayah 6SX1-T-2D Solar cell-continuous flow injection analyser. Iraqi Journal of Science Vol. 56, no. 2B (2015), pp.1224-1240.
https://search.emarefa.net/detail/BIM-596699
American Medical Association (AMA)
al-Awdi, Naghm Shakir Turki& al-Saidi, Kafah Hasan Ismail. Turbidimetric determination of metoclopramide hydrochloride in pharmaceutical preparation via the use of a new homemade Ayah 6SX1-T-2D Solar cell-continuous flow injection analyser. Iraqi Journal of Science. 2015. Vol. 56, no. 2B, pp.1224-1240.
https://search.emarefa.net/detail/BIM-596699
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-596699