Synthesis and characterization of some new N-saccharin derivatives

العناوين الأخرى

تحضير وتشخيص بعض المشتقات الجديدة ل N-سكرين

مقدم أطروحة جامعية

Abd Allah, Asil Farhan

مشرف أطروحة جامعية

Nasir, Ahmad Wahid

الجامعة

جامعة بغداد

الكلية

كلية العلوم

القسم الأكاديمي

قسم الكيمياء

دولة الجامعة

العراق

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2014

الملخص الإنجليزي

Throughout this work, Thirty two of new (N-saccharin) derivatives have been synthesized from ethyl (N-saccharin) acetate [1] as a starting material.

This work is divided into Two parts : the reaction steps for each part are summarized as shown below.

First part: This part involves: A) Synthesis of 1,3 – thiazole [5, 6] and 1,3 –oxazole [7, 8] derivatives via the cyclization of compounds N- (aminocarbonyl) - ∝ -(N-saccharin) acetamide [2] and N- (aminothiocarbonyl)- ∝ -(N- saccharin) acetamide [3] with p-bromophenacyl bromide and p-phenylphenacyl bromide.Scheme[1] B) Synthesis of 1,3 – oxazoline derivatives [11-14] via the reaction of compound ∝- (N- saccharin) acetohydrazide [4] with phenylisocynate and 1- naphthylisocynate and cyclization of the resulted products with p-boromophenacyl bromide and p-phenylphenacyl bromide.Scheme[1] C) Synthesis of cyclicimide derivatives [15-17] via the reaction of compound ∝- (N- saccharin) acetohydrazide [4] with some acid anhydride, such as maleic anhydride, succinic anhydride and phthalic anhydride.Scheme[1] VI Second part:- This part involves: A) Synthesis of azitidine derivatives [21-23] from the cyclization of new Schiff- base derivatives [18-20] with chloroacetyl choride in the presence of triethylamine.Scheme[2] B) Synthesis of oxazpein derivatives [24-32] from the cyclization of prepared Schiff- bases [18-20] with some acid anhydride, such as maleic anhydride, succinic anhydride and phthalic anhydride .Scheme[2] The new prepared compounds have been identified by melting points and TLC and FT.IR and 1-HNMR spectra.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

94

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-599691