Synthesis and characterization of some new N-saccharin derivatives

Other Title(s)

تحضير وتشخيص بعض المشتقات الجديدة ل N-سكرين

Dissertant

Abd Allah, Asil Farhan

Thesis advisor

Nasir, Ahmad Wahid

University

University of Baghdad

Faculty

College of Science

Department

Chemistry Department

University Country

Iraq

Degree

Master

Degree Date

2014

English Abstract

Throughout this work, Thirty two of new (N-saccharin) derivatives have been synthesized from ethyl (N-saccharin) acetate [1] as a starting material.

This work is divided into Two parts : the reaction steps for each part are summarized as shown below.

First part: This part involves: A) Synthesis of 1,3 – thiazole [5, 6] and 1,3 –oxazole [7, 8] derivatives via the cyclization of compounds N- (aminocarbonyl) - ∝ -(N-saccharin) acetamide [2] and N- (aminothiocarbonyl)- ∝ -(N- saccharin) acetamide [3] with p-bromophenacyl bromide and p-phenylphenacyl bromide.Scheme[1] B) Synthesis of 1,3 – oxazoline derivatives [11-14] via the reaction of compound ∝- (N- saccharin) acetohydrazide [4] with phenylisocynate and 1- naphthylisocynate and cyclization of the resulted products with p-boromophenacyl bromide and p-phenylphenacyl bromide.Scheme[1] C) Synthesis of cyclicimide derivatives [15-17] via the reaction of compound ∝- (N- saccharin) acetohydrazide [4] with some acid anhydride, such as maleic anhydride, succinic anhydride and phthalic anhydride.Scheme[1] VI Second part:- This part involves: A) Synthesis of azitidine derivatives [21-23] from the cyclization of new Schiff- base derivatives [18-20] with chloroacetyl choride in the presence of triethylamine.Scheme[2] B) Synthesis of oxazpein derivatives [24-32] from the cyclization of prepared Schiff- bases [18-20] with some acid anhydride, such as maleic anhydride, succinic anhydride and phthalic anhydride .Scheme[2] The new prepared compounds have been identified by melting points and TLC and FT.IR and 1-HNMR spectra.

Main Subjects

Chemistry

No. of Pages

94

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-599691