Spectroscopic studies and analysis of complexes via the reaction of selected ligands with some metal ions

العناوين الأخرى

دراسات طيفية و تحليلية لمعقدات محضرة من خلال تفاعل ليكندات منتخبة مع بعض الأيونات الفلزية

مقدم أطروحة جامعية

al-Kuwaz, Huda Muayyad Nafi

مشرف أطروحة جامعية

al-Abdaliy, Basim Ibrahim
al-Hashimi, Isam Muhammad Ali Shakir

الجامعة

جامعة بغداد

الكلية

كلية العلوم

القسم الأكاديمي

قسم الكيمياء

دولة الجامعة

العراق

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2011

الملخص الإنجليزي

Newly developed spectrophotometric method was used in the present research project for the determination of metformin drug (MTF), via the complexation of the drug with copper(II).

The colored product was measured at 530 nm.

The optimization of all chemical and physical parameters for MTF-OH--Cu(II) system are described.

A linear range of 94.04% for 0.0-100 mM was obtained with a Limit of Detection (L.O.D) 662 ng.

The newly developed system was applied for the analysis of pharmaceutical preparation.

A comparison was made using paired t-test shows that, the newly developed method can be used as an alternative analytical method for the analysis of metformin (MTF).

All this project work was based on on-line determination via Continuous Flow Injection Analysis (C.F.I.A).

The research project also include, mixed ligand complexes of Cu(II), Ni(II) and Co(II) derived from metformin(MTF) as primary ligand and cysteine as secondary ligand have been prepared and characterized by elemental analyses, atomic absorption, FTIR, electronic spectra, NMR spectra, molar conductivity and magnetic susceptibility measurements.

The elemental analysis, atomic absorption data reveal the formation of [ 1 : 1 : 1 ] [M:MTF:Cys] complexes .The electronic spectra and magnetic moment measurements reveal the presence of the complexes in an octahedral geometry and molar conductivity studies of the complexes indicate their non-electrolytic nature.

The infrared and NMR spectral data showed that the chelation behaviour of the ligands towards transition metal ions is through two imino groups of MTF, whereas the amino acid coordinates through sulphur atom and the amino nitrogen.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

101

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-599972