Spectroscopic studies and analysis of complexes via the reaction of selected ligands with some metal ions
Other Title(s)
دراسات طيفية و تحليلية لمعقدات محضرة من خلال تفاعل ليكندات منتخبة مع بعض الأيونات الفلزية
Dissertant
Thesis advisor
al-Abdaliy, Basim Ibrahim
al-Hashimi, Isam Muhammad Ali Shakir
University
University of Baghdad
Faculty
College of Science
Department
Chemistry Department
University Country
Iraq
Degree
Master
Degree Date
2011
English Abstract
Newly developed spectrophotometric method was used in the present research project for the determination of metformin drug (MTF), via the complexation of the drug with copper(II).
The colored product was measured at 530 nm.
The optimization of all chemical and physical parameters for MTF-OH--Cu(II) system are described.
A linear range of 94.04% for 0.0-100 mM was obtained with a Limit of Detection (L.O.D) 662 ng.
The newly developed system was applied for the analysis of pharmaceutical preparation.
A comparison was made using paired t-test shows that, the newly developed method can be used as an alternative analytical method for the analysis of metformin (MTF).
All this project work was based on on-line determination via Continuous Flow Injection Analysis (C.F.I.A).
The research project also include, mixed ligand complexes of Cu(II), Ni(II) and Co(II) derived from metformin(MTF) as primary ligand and cysteine as secondary ligand have been prepared and characterized by elemental analyses, atomic absorption, FTIR, electronic spectra, NMR spectra, molar conductivity and magnetic susceptibility measurements.
The elemental analysis, atomic absorption data reveal the formation of [ 1 : 1 : 1 ] [M:MTF:Cys] complexes .The electronic spectra and magnetic moment measurements reveal the presence of the complexes in an octahedral geometry and molar conductivity studies of the complexes indicate their non-electrolytic nature.
The infrared and NMR spectral data showed that the chelation behaviour of the ligands towards transition metal ions is through two imino groups of MTF, whereas the amino acid coordinates through sulphur atom and the amino nitrogen.
Main Subjects
No. of Pages
101
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental .
Chapter Three : Preliminary investigated.
Chapter Four : Results and discussions.
References.
American Psychological Association (APA)
al-Kuwaz, Huda Muayyad Nafi. (2011). Spectroscopic studies and analysis of complexes via the reaction of selected ligands with some metal ions. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-599972
Modern Language Association (MLA)
al-Kuwaz, Huda Muayyad Nafi. Spectroscopic studies and analysis of complexes via the reaction of selected ligands with some metal ions. (Master's theses Theses and Dissertations Master). University of Baghdad. (2011).
https://search.emarefa.net/detail/BIM-599972
American Medical Association (AMA)
al-Kuwaz, Huda Muayyad Nafi. (2011). Spectroscopic studies and analysis of complexes via the reaction of selected ligands with some metal ions. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-599972
Language
English
Data Type
Arab Theses
Record ID
BIM-599972
