Synthesis of nucleoside analogues with new type of nitrogen bases

العناوين الأخرى

تحضير مماثلات النيوكليوسيد تحتوي على أنواع جديدة من القواعد النيتروجينية

مقدم أطروحة جامعية

al-Samirrai, Asma Mazin Abd al-Hamid Kazim

مشرف أطروحة جامعية

al-Araji, Suad Mustafa
al-Fattahi, Yusuf Ali

الجامعة

جامعة بغداد

الكلية

كلية العلوم

القسم الأكاديمي

قسم الكيمياء

دولة الجامعة

العراق

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2005

الملخص الإنجليزي

The work in this is divided into three parts.

The first part is the introduction which is concerned with the chemistry of nucleosides including their configuration; classification; broad screening of their biological activity as antitumor, antiviral and antibacterial agents; and their synthesis were reviewed.

The second part deals with the synthesis of new type of nucleoside analogues of D-ribose.

Started with preparing 1, 2, 3, 4-tetra-O-benzoyl-β-Dribopyranose [41] which was obtained from the reaction of anhydrous D-ribose with benzoyl chloride in pyridine.

When [41] was treated with 45% hydrogen bromide solution in glacial acetic acid it gave 2, 3, 4-tri-O-benzoyl-β-Dribopyranosyl bromide [42].

The bromoribobenzoate [42] was then reacted with different kinds of nitrogen bases ( theophylline, phenothiazine, phenoxazine, indol and carbazol ) after being converted to the mercury salts [46], [47], [48], [49] and [50] respectively.

Applying Keonigs-Knorr method the nucleoside analogues derivatives [51], [52], [53], [54] and [55] were obtained.

Debenzoylation of the benzoate groups of [51], [52], [53], [54] and [55] using sodium methoxide as base afforded the free nucleoside analogues [56], [57], [58], [59] and [60].

The third part deals with the discussion of FTIR, UV, H1-NMR and C13- NMR spectral data, measurements.

These results were discussed in this part to give the final conclusion for the preparation of the above nucleoside analogues.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

110

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-600083