Synthesis of nucleoside analogues with new type of nitrogen bases
Other Title(s)
تحضير مماثلات النيوكليوسيد تحتوي على أنواع جديدة من القواعد النيتروجينية
Dissertant
al-Samirrai, Asma Mazin Abd al-Hamid Kazim
Thesis advisor
al-Araji, Suad Mustafa
al-Fattahi, Yusuf Ali
University
University of Baghdad
Faculty
College of Science
Department
Chemistry Department
University Country
Iraq
Degree
Master
Degree Date
2005
English Abstract
The work in this is divided into three parts.
The first part is the introduction which is concerned with the chemistry of nucleosides including their configuration; classification; broad screening of their biological activity as antitumor, antiviral and antibacterial agents; and their synthesis were reviewed.
The second part deals with the synthesis of new type of nucleoside analogues of D-ribose.
Started with preparing 1, 2, 3, 4-tetra-O-benzoyl-β-Dribopyranose [41] which was obtained from the reaction of anhydrous D-ribose with benzoyl chloride in pyridine.
When [41] was treated with 45% hydrogen bromide solution in glacial acetic acid it gave 2, 3, 4-tri-O-benzoyl-β-Dribopyranosyl bromide [42].
The bromoribobenzoate [42] was then reacted with different kinds of nitrogen bases ( theophylline, phenothiazine, phenoxazine, indol and carbazol ) after being converted to the mercury salts [46], [47], [48], [49] and [50] respectively.
Applying Keonigs-Knorr method the nucleoside analogues derivatives [51], [52], [53], [54] and [55] were obtained.
Debenzoylation of the benzoate groups of [51], [52], [53], [54] and [55] using sodium methoxide as base afforded the free nucleoside analogues [56], [57], [58], [59] and [60].
The third part deals with the discussion of FTIR, UV, H1-NMR and C13- NMR spectral data, measurements.
These results were discussed in this part to give the final conclusion for the preparation of the above nucleoside analogues.
Main Subjects
No. of Pages
110
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental.
Chapter Three : Results and discussion.
References.
American Psychological Association (APA)
al-Samirrai, Asma Mazin Abd al-Hamid Kazim. (2005). Synthesis of nucleoside analogues with new type of nitrogen bases. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-600083
Modern Language Association (MLA)
al-Samirrai, Asma Mazin Abd al-Hamid Kazim. Synthesis of nucleoside analogues with new type of nitrogen bases. (Master's theses Theses and Dissertations Master). University of Baghdad. (2005).
https://search.emarefa.net/detail/BIM-600083
American Medical Association (AMA)
al-Samirrai, Asma Mazin Abd al-Hamid Kazim. (2005). Synthesis of nucleoside analogues with new type of nitrogen bases. (Master's theses Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-600083
Language
English
Data Type
Arab Theses
Record ID
BIM-600083
