Synthesis and characterization of heterocyclic derivatives from 2-azo benzothiazole

العناوين الأخرى

تحضير و تشخيص مشتقات جديدة غير متجانسة للمركب 2-ازوبنزوثايازول

مقدم أطروحة جامعية

Mahmud, Maha Qasim

مشرف أطروحة جامعية

al-Tamimi, Intisar Uayd Prisse

الجامعة

جامعة بغداد

الكلية

كلية العلوم

القسم الأكاديمي

قسم الكيمياء

دولة الجامعة

العراق

الدرجة العلمية

دكتوراه

تاريخ الدرجة العلمية

2012

الملخص الإنجليزي

Several benzothiazole derivatives have long been known for their diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents.

Azo compounds also have biological activity.

In addition, 1,2,4-triazole,1,3,4-thiadiazole and 1,3,4-oxadiazole, were reported to constitute the pharmacologically active moiety of several compounds.

On these bases, new series of 2-azobenzothiazole derivatives, in which the adamantly moiety was attached to 1,2,4-triazole, 1,3,4- thiadiazole and 1,3,4-oxadiazole nucleus, have been synthesized as possible potential bioactive agents.

In order to obtain the target compounds, the following routes were adopted :- 1- Preparation of 2-amino benzothiazole and their derivatives (1-5), from reaction of r- substituted aniline with ammonium thiocyanate in the present of bromine as catalyst.

2- Involved diazotation and coupling reaction to form azo compounds by converted amino group to dizonum salt by react with NaNO2 / H2SO4 in low temperatures then coupling with substituted phenols to yield compounds (6-45).

3- Reaction of coupled products with ethyl 2-bromo propionate and anhydrous K2CO3 in dry acetone to yield the new ester derivatives (46 -62 ).

4- The ester group was converted to N-substituted thiosemicarbazide by reaction with thiosemicarbazide in absolute ethanol to form compounds ( 63 -70).

5- Also the ester group was converted to N-substituted semicarbazide by reaction with semicarbazide in absolute ethanol to form compounds (71-78).

6- The N-substituted semicarbazide react with acid to yield 5- {substituted}2-amino-1,3,4-oxadiazole (79-86).

XXVIII 7- The N-substituted thiosemicarbazide react with base to yield 5-{substituted} 2-amino 1,2,4-triazole (87-94), also react with acid to form 5-{substituted}2-amino 1,3,4- thiadiazole ( 95-102).

التخصصات الرئيسية

الكيمياء

الموضوعات

• مقاييس الطيف
• البصريات
• الضوء
• الكيمياء التحليلية
• أطياف الامتصاص

عدد الصفحات

229

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-600561