Synthesis and characterization of heterocyclic derivatives from 2-azo benzothiazole
Other Title(s)
تحضير و تشخيص مشتقات جديدة غير متجانسة للمركب 2-ازوبنزوثايازول
Dissertant
Thesis advisor
al-Tamimi, Intisar Uayd Prisse
University
University of Baghdad
Faculty
College of Science
Department
Chemistry Department
University Country
Iraq
Degree
Ph.D.
Degree Date
2012
English Abstract
Several benzothiazole derivatives have long been known for their diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents.
Azo compounds also have biological activity.
In addition, 1,2,4-triazole,1,3,4-thiadiazole and 1,3,4-oxadiazole, were reported to constitute the pharmacologically active moiety of several compounds.
On these bases, new series of 2-azobenzothiazole derivatives, in which the adamantly moiety was attached to 1,2,4-triazole, 1,3,4- thiadiazole and 1,3,4-oxadiazole nucleus, have been synthesized as possible potential bioactive agents.
In order to obtain the target compounds, the following routes were adopted :- 1- Preparation of 2-amino benzothiazole and their derivatives (1-5), from reaction of r- substituted aniline with ammonium thiocyanate in the present of bromine as catalyst.
2- Involved diazotation and coupling reaction to form azo compounds by converted amino group to dizonum salt by react with NaNO2 / H2SO4 in low temperatures then coupling with substituted phenols to yield compounds (6-45).
3- Reaction of coupled products with ethyl 2-bromo propionate and anhydrous K2CO3 in dry acetone to yield the new ester derivatives (46 -62 ).
4- The ester group was converted to N-substituted thiosemicarbazide by reaction with thiosemicarbazide in absolute ethanol to form compounds ( 63 -70).
5- Also the ester group was converted to N-substituted semicarbazide by reaction with semicarbazide in absolute ethanol to form compounds (71-78).
6- The N-substituted semicarbazide react with acid to yield 5- {substituted}2-amino-1,3,4-oxadiazole (79-86).
XXVIII 7- The N-substituted thiosemicarbazide react with base to yield 5-{substituted} 2-amino 1,2,4-triazole (87-94), also react with acid to form 5-{substituted}2-amino 1,3,4- thiadiazole ( 95-102).
Main Subjects
Topics
No. of Pages
229
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental part.
Chapter Three : Results and discussion.
References.
American Psychological Association (APA)
Mahmud, Maha Qasim. (2012). Synthesis and characterization of heterocyclic derivatives from 2-azo benzothiazole. (Doctoral dissertations Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-600561
Modern Language Association (MLA)
Mahmud, Maha Qasim. Synthesis and characterization of heterocyclic derivatives from 2-azo benzothiazole. (Doctoral dissertations Theses and Dissertations Master). University of Baghdad. (2012).
https://search.emarefa.net/detail/BIM-600561
American Medical Association (AMA)
Mahmud, Maha Qasim. (2012). Synthesis and characterization of heterocyclic derivatives from 2-azo benzothiazole. (Doctoral dissertations Theses and Dissertations Master). University of Baghdad, Iraq
https://search.emarefa.net/detail/BIM-600561
Language
English
Data Type
Arab Theses
Record ID
BIM-600561
