Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience
المؤلفون المشاركون
Anwar, Manal M.
Khalil, Ihab M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 27، العدد 3 (30 سبتمبر/أيلول 2015)، ص ص. 119-128، 10ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2015-09-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Investigate treatment outcome, prognostic factors and survival among selected group of Egyptian pediatric nasopharyngeal carcinoma patients.
Patients and methods: Thirty patients treated from non-metastatic nasopharyngeal carcinoma between 1997 and 2012 were retrospectively evaluated including: TNM staging, chemoradiotherapy regimens.
Survival analysis was done using Kaplan–Meier survival curves.
Results: Twenty-three males and 7 females (M:F 3.2:1) with median age of 14 years; 84% with stages III/IV.
Neck node enlargement was reported in 90% (27/30).
Induction chemotherapy followed by radiotherapy was implemented in 80% of patients.
Mucositis (87%) was the commonest treatment related toxicity.
Nineteen patients (63%) were in CR with a median FU of 69 months (range 24–160).
Eleven patients had treatment local and distant failures (2 local, 7 distant and 2 local/distant) at a median FU of 24 and 34 months respectively.
5-year overall and event-free survival rates were 77% and 63% respectively.
Prolonged OAP of RT P 50 days, Hb < 11 g% and T4 stage affected EFS and OAS on UVA; while on MVA; prolonged OAP of RT P 50 days (p=0.002) and T4 stage (p= 0.004) affected EFS and only Hb <11 g% (p= 0.019) affected OAS.
Late toxicity was reported in 70% of irradiated patients.
Conclusion: Radio-chemotherapy management for pediatric NPC resulted in comparable treatment outcomes with tolerable late effects.
Response adapted radio-chemotherapy regimens in addition to the potential use of IMRT should be recommended to decrease treatment related side effects.
Prolonged OAP of RT P 50 days and low Hb level were encountered as adverse prognostic factors; findings that need further investigation.
ª 2015 The Authors.
Production and hosting by Elsevier B.V.
on behalf of National Cancer Institute, Cairo University.
This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalil, Ihab M.& Anwar, Manal M.. 2015. Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 3, pp.119-128.
https://search.emarefa.net/detail/BIM-600769
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalil, Ihab M.& Anwar, Manal M.. Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience. Journal of the Egyptian National Cancer Institute Vol. 27, no. 3 (Sep. 2015), pp.119-128.
https://search.emarefa.net/detail/BIM-600769
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalil, Ihab M.& Anwar, Manal M.. Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 3, pp.119-128.
https://search.emarefa.net/detail/BIM-600769
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 127-128
رقم السجل
BIM-600769
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر