Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience
Joint Authors
Anwar, Manal M.
Khalil, Ihab M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 27, Issue 3 (30 Sep. 2015), pp.119-128, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background: Investigate treatment outcome, prognostic factors and survival among selected group of Egyptian pediatric nasopharyngeal carcinoma patients.
Patients and methods: Thirty patients treated from non-metastatic nasopharyngeal carcinoma between 1997 and 2012 were retrospectively evaluated including: TNM staging, chemoradiotherapy regimens.
Survival analysis was done using Kaplan–Meier survival curves.
Results: Twenty-three males and 7 females (M:F 3.2:1) with median age of 14 years; 84% with stages III/IV.
Neck node enlargement was reported in 90% (27/30).
Induction chemotherapy followed by radiotherapy was implemented in 80% of patients.
Mucositis (87%) was the commonest treatment related toxicity.
Nineteen patients (63%) were in CR with a median FU of 69 months (range 24–160).
Eleven patients had treatment local and distant failures (2 local, 7 distant and 2 local/distant) at a median FU of 24 and 34 months respectively.
5-year overall and event-free survival rates were 77% and 63% respectively.
Prolonged OAP of RT P 50 days, Hb < 11 g% and T4 stage affected EFS and OAS on UVA; while on MVA; prolonged OAP of RT P 50 days (p=0.002) and T4 stage (p= 0.004) affected EFS and only Hb <11 g% (p= 0.019) affected OAS.
Late toxicity was reported in 70% of irradiated patients.
Conclusion: Radio-chemotherapy management for pediatric NPC resulted in comparable treatment outcomes with tolerable late effects.
Response adapted radio-chemotherapy regimens in addition to the potential use of IMRT should be recommended to decrease treatment related side effects.
Prolonged OAP of RT P 50 days and low Hb level were encountered as adverse prognostic factors; findings that need further investigation.
ª 2015 The Authors.
Production and hosting by Elsevier B.V.
on behalf of National Cancer Institute, Cairo University.
This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
American Psychological Association (APA)
Khalil, Ihab M.& Anwar, Manal M.. 2015. Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience. Journal of the Egyptian National Cancer Institute،Vol. 27, no. 3, pp.119-128.
https://search.emarefa.net/detail/BIM-600769
Modern Language Association (MLA)
Khalil, Ihab M.& Anwar, Manal M.. Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience. Journal of the Egyptian National Cancer Institute Vol. 27, no. 3 (Sep. 2015), pp.119-128.
https://search.emarefa.net/detail/BIM-600769
American Medical Association (AMA)
Khalil, Ihab M.& Anwar, Manal M.. Treatment results of pediatric nasopharyngeal carcinoma, NCI, Cairo University experience. Journal of the Egyptian National Cancer Institute. 2015. Vol. 27, no. 3, pp.119-128.
https://search.emarefa.net/detail/BIM-600769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 127-128
Record ID
BIM-600769