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Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents
المؤلفون المشاركون
al-Umran, Abd Allah S.
Azam, Quamar
المصدر
العدد
المجلد 36، العدد 3 (30 سبتمبر/أيلول 2014)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2014-09-30
دولة النشر
البحرين
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : In 2008, Osteoarthritis Research Society International (OARSI) cited intra-articular (IA) injection of hyaluronic acid (HA) as a useful therapeutic modality, which relieves pain and functional score and delays progress of Osteoarthritis.
Currently, there are more than five HA formulations in the market approved commonly used for intra-articular (IA) injection.
Objective : To compare the efficacy of the three commonly used injections in a cohort population.
Design : A Prospective Randomized Study.
Setting : King Fahd Hospital of the University, Al Khobar.
Method : Two hundred twenty-seven patients with grade 1, 2 and 3 OA were included in the study.
Three different intra-articular injections of HA were used after double blinding: Osteonil (Sodium hyaluronate, TRB Chemedica UK ltd), Durolane (stabilized form of hyaluronic acid, Bioventus) and Synvisc (hylan GF-20, Sanofi Biosurgery).
The data were analyzed using Stata SE/v.12.
Analysis of variance followed by a post hoc t-test (LSD) was used for inferential statistical analysis.
Result : Group A had 78 patients, group B 74 patients and group C 75 patients.
Analysis of variance showed that the efficacy of the treatment differed significantly (F = 53.34, df1 = 2, df2 = 207, p-Value < 0.001).
The result of the post-hoc tests showed Synvisc Injection was the most effective showing significant improvement than both Osteonil Injection (mean diff = 7.68, p < 0.001, CI = 4.73, 10.64) and Durolane Injection (mean diff = 15.61, p < 0.001, CI = 12.63, 18.59).
Osteonil Injection was found to be superior to Durolane Injection (mean diff = 7.93, p < 0.001, CI = 10.89725, 4.957825).
Conclusion : Viscosupplement (VS) agents provide significant though temporary symptomatic relief in grade 2 and 3 OA.
The efficacy of all three agents was similar with marginal superiority of one over the other.
Considering excellent tolerability, viscosupplementation may be included in the armamentarium of OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Umran, Abd Allah S.& Azam, Quamar. 2014. Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents. Bahrain Medical Bulletin،Vol. 36, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-603724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Umran, Abd Allah S.& Azam, Quamar. Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents. Bahrain Medical Bulletin Vol. 36, no. 3 (Sep. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-603724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Umran, Abd Allah S.& Azam, Quamar. Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents. Bahrain Medical Bulletin. 2014. Vol. 36, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-603724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-603724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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