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Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents
Joint Authors
al-Umran, Abd Allah S.
Azam, Quamar
Source
Issue
Vol. 36, Issue 3 (30 Sep. 2014), pp.1-8, 8 p.
Publisher
King Hamad University Hospital
Publication Date
2014-09-30
Country of Publication
Bahrain
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : In 2008, Osteoarthritis Research Society International (OARSI) cited intra-articular (IA) injection of hyaluronic acid (HA) as a useful therapeutic modality, which relieves pain and functional score and delays progress of Osteoarthritis.
Currently, there are more than five HA formulations in the market approved commonly used for intra-articular (IA) injection.
Objective : To compare the efficacy of the three commonly used injections in a cohort population.
Design : A Prospective Randomized Study.
Setting : King Fahd Hospital of the University, Al Khobar.
Method : Two hundred twenty-seven patients with grade 1, 2 and 3 OA were included in the study.
Three different intra-articular injections of HA were used after double blinding: Osteonil (Sodium hyaluronate, TRB Chemedica UK ltd), Durolane (stabilized form of hyaluronic acid, Bioventus) and Synvisc (hylan GF-20, Sanofi Biosurgery).
The data were analyzed using Stata SE/v.12.
Analysis of variance followed by a post hoc t-test (LSD) was used for inferential statistical analysis.
Result : Group A had 78 patients, group B 74 patients and group C 75 patients.
Analysis of variance showed that the efficacy of the treatment differed significantly (F = 53.34, df1 = 2, df2 = 207, p-Value < 0.001).
The result of the post-hoc tests showed Synvisc Injection was the most effective showing significant improvement than both Osteonil Injection (mean diff = 7.68, p < 0.001, CI = 4.73, 10.64) and Durolane Injection (mean diff = 15.61, p < 0.001, CI = 12.63, 18.59).
Osteonil Injection was found to be superior to Durolane Injection (mean diff = 7.93, p < 0.001, CI = 10.89725, 4.957825).
Conclusion : Viscosupplement (VS) agents provide significant though temporary symptomatic relief in grade 2 and 3 OA.
The efficacy of all three agents was similar with marginal superiority of one over the other.
Considering excellent tolerability, viscosupplementation may be included in the armamentarium of OA.
American Psychological Association (APA)
al-Umran, Abd Allah S.& Azam, Quamar. 2014. Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents. Bahrain Medical Bulletin،Vol. 36, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-603724
Modern Language Association (MLA)
al-Umran, Abd Allah S.& Azam, Quamar. Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents. Bahrain Medical Bulletin Vol. 36, no. 3 (Sep. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-603724
American Medical Association (AMA)
al-Umran, Abd Allah S.& Azam, Quamar. Efficacy of viscosupplementation in knee osteoarthritis : a clinical trial of three agents. Bahrain Medical Bulletin. 2014. Vol. 36, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-603724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-603724