Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome
المؤلفون المشاركون
Adeyemi, Edward O.
Obineche, Enyioma N.
Abd Allah, Abd al-ShakurShakur
Usamah, Abd al-Rahman
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 12، العدد 2 (30 إبريل/نيسان 2001)، ص ص. 151-156، 6ص.
الناشر
تاريخ النشر
2001-04-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
In patients with the nephrotic syndrome, it is often desirable to assess the disease process, not only by proteinuria but also by indices of glomerular inflammatory process.
We investigated the importance of 2-microglobulin (2M) as a means of assessing renal function in patients with the nephrotic syndrome with normal or abnormal values of creatinine clearance.
There were 46 patients (mean age, 42.2 + 10.4 years ; male / female (M / F) ratio = 31 / 15) and 35 healthy controls (mean age 39 + 4.5 years, M / F ratio 25 / 10).
We subdivided the study patients into group A (n = 18, mean age 39.6 + 10.6 years, M / F ratio 8 / 10) and group B patients (n = 28, mean age 45.6 + 8.9 years, M / F ratio 23 / 5) who had normal and abnormal values of creatinine clearance respectively.
An enzyme-linked-immunosorbent assay (ELISA) was used to quantitate plasma 2M in the study patients and controls.
The median 2M levels of the study patients and controls were 44.0 and 1.7 mg / l respectively (p < 0.0001).
Beta-2-M levels correlated significantly with serum creatinine (r = 0.56, p < 0.0001), and creatinine clearance (r = -0.6, p < 0.0001).
In group A patients, the median 2M level was significantly higher than normal (4.1 vs.
1.7 mg / 1, p < 0.01).
Plasma 2M levels did not correlate well with any other parameter measured in group A patients.
When groups A and B were compared, the median plasma 2M level in group B was significantly higher than group A (20.3 vs.
4.1 mg / 1, p < 0.0001).
The urinary 2M (expressed per mg urine creatinine) was also higher in group B than group A patients (6.8 vs.
0.7 p < 0.05).
We conclude that elevation of 2M-microglobulin in patients with the nephrotic syndrome who have normal creatinine clearance suggests early abnormal renal function in these patients.
It may be used to assess the rate of normalisation of renal function or progression to chronic renal failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adeyemi, Edward O.& Obineche, Enyioma N.& Abd Allah, Abd al-ShakurShakur& Usamah, Abd al-Rahman. 2001. Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 12, no. 2, pp.151-156.
https://search.emarefa.net/detail/BIM-60701
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adeyemi, Edward O.…[et al.]. Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 12, no. 2 (Apr. 2001), pp.151-156.
https://search.emarefa.net/detail/BIM-60701
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adeyemi, Edward O.& Obineche, Enyioma N.& Abd Allah, Abd al-ShakurShakur& Usamah, Abd al-Rahman. Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2001. Vol. 12, no. 2, pp.151-156.
https://search.emarefa.net/detail/BIM-60701
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 15-156
رقم السجل
BIM-60701
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر