Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome
Joint Authors
Adeyemi, Edward O.
Obineche, Enyioma N.
Abd Allah, Abd al-ShakurShakur
Usamah, Abd al-Rahman
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 12, Issue 2 (30 Apr. 2001), pp.151-156, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2001-04-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
In patients with the nephrotic syndrome, it is often desirable to assess the disease process, not only by proteinuria but also by indices of glomerular inflammatory process.
We investigated the importance of 2-microglobulin (2M) as a means of assessing renal function in patients with the nephrotic syndrome with normal or abnormal values of creatinine clearance.
There were 46 patients (mean age, 42.2 + 10.4 years ; male / female (M / F) ratio = 31 / 15) and 35 healthy controls (mean age 39 + 4.5 years, M / F ratio 25 / 10).
We subdivided the study patients into group A (n = 18, mean age 39.6 + 10.6 years, M / F ratio 8 / 10) and group B patients (n = 28, mean age 45.6 + 8.9 years, M / F ratio 23 / 5) who had normal and abnormal values of creatinine clearance respectively.
An enzyme-linked-immunosorbent assay (ELISA) was used to quantitate plasma 2M in the study patients and controls.
The median 2M levels of the study patients and controls were 44.0 and 1.7 mg / l respectively (p < 0.0001).
Beta-2-M levels correlated significantly with serum creatinine (r = 0.56, p < 0.0001), and creatinine clearance (r = -0.6, p < 0.0001).
In group A patients, the median 2M level was significantly higher than normal (4.1 vs.
1.7 mg / 1, p < 0.01).
Plasma 2M levels did not correlate well with any other parameter measured in group A patients.
When groups A and B were compared, the median plasma 2M level in group B was significantly higher than group A (20.3 vs.
4.1 mg / 1, p < 0.0001).
The urinary 2M (expressed per mg urine creatinine) was also higher in group B than group A patients (6.8 vs.
0.7 p < 0.05).
We conclude that elevation of 2M-microglobulin in patients with the nephrotic syndrome who have normal creatinine clearance suggests early abnormal renal function in these patients.
It may be used to assess the rate of normalisation of renal function or progression to chronic renal failure.
American Psychological Association (APA)
Adeyemi, Edward O.& Obineche, Enyioma N.& Abd Allah, Abd al-ShakurShakur& Usamah, Abd al-Rahman. 2001. Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 12, no. 2, pp.151-156.
https://search.emarefa.net/detail/BIM-60701
Modern Language Association (MLA)
Adeyemi, Edward O.…[et al.]. Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 12, no. 2 (Apr. 2001), pp.151-156.
https://search.emarefa.net/detail/BIM-60701
American Medical Association (AMA)
Adeyemi, Edward O.& Obineche, Enyioma N.& Abd Allah, Abd al-ShakurShakur& Usamah, Abd al-Rahman. Evaluation of plasma beta-2-microglobulin in patients with the nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2001. Vol. 12, no. 2, pp.151-156.
https://search.emarefa.net/detail/BIM-60701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 15-156
Record ID
BIM-60701