Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels
المؤلفون المشاركون
Tripathi, Vidyanand
Bansal, Savita
Alok, Sharma
Ravi, Bansal
Saxena, Sanjiv
Devra, Amit K.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 26، العدد 5 (30 سبتمبر/أيلول 2015)، ص ص. 884-889، 6ص.
الناشر
تاريخ النشر
2015-09-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
- المرضى
- الكلى
- الأمراض
- الشريان الكعبري
- الهرمون الجار درقي
- التغيرات النسيجية
- المضاعفات(الطب)
- الفشل الكلوي
- الناسور الشرياني الوريدي
الملخص EN
Vascular complications arise in uremic patients in the absence of clinically significant atherosclerotic disease.
Elevated serum parathyroid hormone (PTH) and abnormal calcium (Ca) and phosphorus (P) balance have been implicated in vascular damage in chronic kidney disease (CKD) patients, but there is lack of histo-pathological studies.
Patients with CKD stage 5 and 5D who underwent arterio-venous fistula were included in this study.
Baseline and laboratory parameters including assessment of total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglycerides, uric acid, albumin, calcium, phosphorus, intact PTH (iPTH) and vitamin D level were documented.
The specimens of the arterial wall were obtained during the procedure and were analyzed.
Patients were divided into two groups - iPTH <400 (Group A) and iPTH >400 (Group B).
Mean intimal thickness (IT) was significantly high in patients of Group B (60.4 ± 24.1 μm) as compared with patients of Group A (37.8 ± 14.9 μm) (P = 0.003).
Vascular calcification was comparable in both groups.
The iPTH level was found to be an independent risk factor for high intima thickness (correlation coefficient 0.653) (P-value <0.01).
Patients with high (≥400 pg/mL) iPTH have 8.93 times the risk of developing intimal thickness of ≥60 μm as compared with patients with low (<400 pg/mL) iPTH (P-value <0.05), with 95% confidence interval of 1.27, 62.61.
The mean IT of the radial artery significantly correlated with the iPTH level, while vascular calcification was independent of the iPTH level.
Hyperparathyroidism is an important cause of ongoing vascular damage and may contribute to higher vascular events in CKD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tripathi, Vidyanand& Bansal, Savita& Alok, Sharma& Ravi, Bansal& Devra, Amit K.& Saxena, Sanjiv. 2015. Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 5, pp.884-889.
https://search.emarefa.net/detail/BIM-608586
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alok, Sharma…[et al.]. Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 5 (Sep. 2015), pp.884-889.
https://search.emarefa.net/detail/BIM-608586
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tripathi, Vidyanand& Bansal, Savita& Alok, Sharma& Ravi, Bansal& Devra, Amit K.& Saxena, Sanjiv. Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 5, pp.884-889.
https://search.emarefa.net/detail/BIM-608586
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 888-889
رقم السجل
BIM-608586
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر