Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels
Joint Authors
Tripathi, Vidyanand
Bansal, Savita
Alok, Sharma
Ravi, Bansal
Saxena, Sanjiv
Devra, Amit K.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 26, Issue 5 (30 Sep. 2015), pp.884-889, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2015-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
- Patients
- Kidneys
- Diseases
- Radial artery
- Parathyroid hormone
- Histopathology changes
- Complications(Medicine)
- Kidney failure
- Arteriovenous fistula
Abstract EN
Vascular complications arise in uremic patients in the absence of clinically significant atherosclerotic disease.
Elevated serum parathyroid hormone (PTH) and abnormal calcium (Ca) and phosphorus (P) balance have been implicated in vascular damage in chronic kidney disease (CKD) patients, but there is lack of histo-pathological studies.
Patients with CKD stage 5 and 5D who underwent arterio-venous fistula were included in this study.
Baseline and laboratory parameters including assessment of total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglycerides, uric acid, albumin, calcium, phosphorus, intact PTH (iPTH) and vitamin D level were documented.
The specimens of the arterial wall were obtained during the procedure and were analyzed.
Patients were divided into two groups - iPTH <400 (Group A) and iPTH >400 (Group B).
Mean intimal thickness (IT) was significantly high in patients of Group B (60.4 ± 24.1 μm) as compared with patients of Group A (37.8 ± 14.9 μm) (P = 0.003).
Vascular calcification was comparable in both groups.
The iPTH level was found to be an independent risk factor for high intima thickness (correlation coefficient 0.653) (P-value <0.01).
Patients with high (≥400 pg/mL) iPTH have 8.93 times the risk of developing intimal thickness of ≥60 μm as compared with patients with low (<400 pg/mL) iPTH (P-value <0.05), with 95% confidence interval of 1.27, 62.61.
The mean IT of the radial artery significantly correlated with the iPTH level, while vascular calcification was independent of the iPTH level.
Hyperparathyroidism is an important cause of ongoing vascular damage and may contribute to higher vascular events in CKD patients.
American Psychological Association (APA)
Tripathi, Vidyanand& Bansal, Savita& Alok, Sharma& Ravi, Bansal& Devra, Amit K.& Saxena, Sanjiv. 2015. Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels. Saudi Journal of Kidney Diseases and Transplantation،Vol. 26, no. 5, pp.884-889.
https://search.emarefa.net/detail/BIM-608586
Modern Language Association (MLA)
Alok, Sharma…[et al.]. Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels. Saudi Journal of Kidney Diseases and Transplantation Vol. 26, no. 5 (Sep. 2015), pp.884-889.
https://search.emarefa.net/detail/BIM-608586
American Medical Association (AMA)
Tripathi, Vidyanand& Bansal, Savita& Alok, Sharma& Ravi, Bansal& Devra, Amit K.& Saxena, Sanjiv. Histopathological changes of radial artery wall in patients of chronic kidney disease stage 5 undergoing AV fistula formation and their correlation with serum iPTH levels. Saudi Journal of Kidney Diseases and Transplantation. 2015. Vol. 26, no. 5, pp.884-889.
https://search.emarefa.net/detail/BIM-608586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 888-889
Record ID
BIM-608586