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Toxic effects of cypermethrin on liver and kidney of male domestic rabbits
العناوين الأخرى
أثر سمية السيبرميثرين علي الكبد و الكلية في ذكور الأرانب المحلية
مقدم أطروحة جامعية
مشرف أطروحة جامعية
أعضاء اللجنة
Abd Rabbih, Abd al-Fattah Nazmi
al-Yaziji, Nihad Rafiq
الجامعة
الجامعة الإسلامية
الكلية
كلية العلوم
القسم الأكاديمي
قسم العلوم الحياتية
دولة الجامعة
فلسطين (قطاع غزة)
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2015
الملخص الإنجليزي
Objective: The present study is aimed to investigate the toxic effects of cypermethrin on liver and kidney of male domestic rabbits.
Materials and Methods: The oral LD50 of cypermethrin in male domestic rabbit was calculated from logarithmic scale and found to be 665 mg/kg-1 body weight.
A daily dose of 1/10 LD50 cypermethrin (66.5 mg/kg-1 body weight) was given orally to 36 animals under experiment for six weeks.
Forty eight control animals were given distilled water.
Blood samples were collected weekly and analyzed.
Results: The overall mortality rate was 16.7% in cypermethrin-treated rabbits compared to 0.0% in controls.
Clinical signs included diarrhea, disorientation, drowsiness and mild tremor.
The final body weight was significantly decreased in cypermethrin-intoxicated rabbits.
Serum glucose was significantly increased in response to cypermethrin administration recording a maximum percentage difference of 28.1% in the 6th week of the experiment.
The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (-GT) were significantly higher in cypermethrin-treated rabbits compared to controls, registering maximum percentage differences of 30.1, 38.3, 23.1 and 27.5% during the 4th,1st, 2nd and 6th weeks of the experiment, respectively.
In contrast, serum cholinesterase (ChE) was markedly decreased recording a maximum percentage difference of 46.5% during the 5th week of the experiment.
Serum bilirubin was gradually increased to record a maximum percentage difference of 21.4% in the 5th week.
Serum urea and creatinine concentrations were significantly elevated in response to cypermethrin intake displaying maximum percentage differences of 48.8% and 31.3% during the 6th and 5th weeks of the experiment, respectively.
Serum total protein, albumin and globulin were significantly decreased upon cypermethrin intoxication exhibiting percentage differences of 31.3, 31.8 and 29.4% at the last week of the experiment.
Serum calcium was significantly decreased in cypermethrin-treated rabbits with a maximum percentage difference of 28.6% at the 6th week whereas phosphorus significantly increased with a maximum percentage difference of 24.3% at the 6th week of the experiment.
Conclusions: Oral daily administration of 1/10 LD50 cypermethrin caused significant decrease in body weight, serum cholinesterase, total protein, albumin, globulin and calcium whereas serum glucose, ALT, AST, ALP,-GT, bilirubin, urea, creatinine and phosphorous were significantly increased
التخصصات الرئيسية
الموضوعات
عدد الصفحات
74
قائمة المحتويات
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Materials and methods.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ulwan, Ali Khalid Muhammad. (2015). Toxic effects of cypermethrin on liver and kidney of male domestic rabbits. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-610775
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ulwan, Ali Khalid Muhammad. Toxic effects of cypermethrin on liver and kidney of male domestic rabbits. (Master's theses Theses and Dissertations Master). Islamic University. (2015).
https://search.emarefa.net/detail/BIM-610775
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ulwan, Ali Khalid Muhammad. (2015). Toxic effects of cypermethrin on liver and kidney of male domestic rabbits. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-610775
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-610775
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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