Toxic effects of cypermethrin on liver and kidney of male domestic rabbits

Other Title(s)

أثر سمية السيبرميثرين علي الكبد و الكلية في ذكور الأرانب المحلية

Dissertant

Ulwan, Ali Khalid Muhammad

Thesis advisor

Yasin, Majid Muhammad

Comitee Members

Abd Rabbih, Abd al-Fattah Nazmi
al-Yaziji, Nihad Rafiq

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2015

English Abstract

Objective: The present study is aimed to investigate the toxic effects of cypermethrin on liver and kidney of male domestic rabbits.

Materials and Methods: The oral LD50 of cypermethrin in male domestic rabbit was calculated from logarithmic scale and found to be 665 mg/kg-1 body weight.

A daily dose of 1/10 LD50 cypermethrin (66.5 mg/kg-1 body weight) was given orally to 36 animals under experiment for six weeks.

Forty eight control animals were given distilled water.

Blood samples were collected weekly and analyzed.

Results: The overall mortality rate was 16.7% in cypermethrin-treated rabbits compared to 0.0% in controls.

Clinical signs included diarrhea, disorientation, drowsiness and mild tremor.

The final body weight was significantly decreased in cypermethrin-intoxicated rabbits.

Serum glucose was significantly increased in response to cypermethrin administration recording a maximum percentage difference of 28.1% in the 6th week of the experiment.

The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (-GT) were significantly higher in cypermethrin-treated rabbits compared to controls, registering maximum percentage differences of 30.1, 38.3, 23.1 and 27.5% during the 4th,1st, 2nd and 6th weeks of the experiment, respectively.

In contrast, serum cholinesterase (ChE) was markedly decreased recording a maximum percentage difference of 46.5% during the 5th week of the experiment.

Serum bilirubin was gradually increased to record a maximum percentage difference of 21.4% in the 5th week.

Serum urea and creatinine concentrations were significantly elevated in response to cypermethrin intake displaying maximum percentage differences of 48.8% and 31.3% during the 6th and 5th weeks of the experiment, respectively.

Serum total protein, albumin and globulin were significantly decreased upon cypermethrin intoxication exhibiting percentage differences of 31.3, 31.8 and 29.4% at the last week of the experiment.

Serum calcium was significantly decreased in cypermethrin-treated rabbits with a maximum percentage difference of 28.6% at the 6th week whereas phosphorus significantly increased with a maximum percentage difference of 24.3% at the 6th week of the experiment.

Conclusions: Oral daily administration of 1/10 LD50 cypermethrin caused significant decrease in body weight, serum cholinesterase, total protein, albumin, globulin and calcium whereas serum glucose, ALT, AST, ALP,-GT, bilirubin, urea, creatinine and phosphorous were significantly increased

Main Subjects

Biology
Zoology

Topics

• Physiology

No. of Pages

74

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-610775