Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum
المؤلفون المشاركون
al-Sadi, Warka T.
al-Tai, Anwar F.
Mahmud, Ali K.
al-Said, Hasan H.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 57، العدد 3 (30 سبتمبر/أيلول 2015)، ص ص. 254-256، 3ص.
الناشر
تاريخ النشر
2015-09-30
دولة النشر
العراق
عدد الصفحات
3
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Heterocyclic compounds and its derivatives have biological activities and used as analgesic, anti-helminthic, antituberculer, antifungal, antiviral, anticancer and inhibitor of some enzymes.
Oxazepine (benzodiazepine) derivative used in relief of psychoneuroses characterized by anxiety and tension.
Alkaline phosphatase (ALP) hydrolyzes phosphate monoesters, while Lactate dehydrogenase (LDH) catalyses oxidation of L-lactate to pyruvate utilizing NAD+ Objective: The study was carried out to know of the impact of 1,3-oxazepine derivative on the ALP and LDH enzyme activity on human serum in vitro.
Methods: The study included the effect of synthesized 1,3-oxazepine divertive [(Z)-3-(5-mercapto-1-3,4-Thiadizol-2-yl)-2-(4-nitrophenyl)-2,3-dihydro-1,3-oxzepine-4,7-dione] on the activity of enzymes ALP and LDH for (34) healthy Iraqi females serum in vitro.
The activity of both enzymes was measured spectrophotometrically.
Different concentrations of 1,3-oxazepine derivative were used and the inhibition percentage was calculated.
Results: The results of this study revealed that effect of 1,3-oxazepine derivative was inhibitor for ALP and LDH activity and the high inhibition percentage was 87.56% for ALP.
The high inhibition percentage was 50% for LDH when 1,3-oxazepine derivative was used.
Conclusions: 1,3-oxazepine derivative affected as inhibitor on ALP and LDH enzyme activity in human serum in vitro.
This can be used in drug industry in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sadi, Warka T.& al-Tai, Anwar F.& al-Said, Hasan H.& Mahmud, Ali K.. 2015. Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum. Journal of the Faculty of Medicine Baghdad،Vol. 57, no. 3, pp.254-256.
https://search.emarefa.net/detail/BIM-617076
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sadi, Warka T.…[et al.]. Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum. Journal of the Faculty of Medicine Baghdad Vol. 57, no. 3 (2015), pp.254-256.
https://search.emarefa.net/detail/BIM-617076
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sadi, Warka T.& al-Tai, Anwar F.& al-Said, Hasan H.& Mahmud, Ali K.. Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum. Journal of the Faculty of Medicine Baghdad. 2015. Vol. 57, no. 3, pp.254-256.
https://search.emarefa.net/detail/BIM-617076
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 255-256
رقم السجل
BIM-617076
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر