Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum
Joint Authors
al-Sadi, Warka T.
al-Tai, Anwar F.
Mahmud, Ali K.
al-Said, Hasan H.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 57, Issue 3 (30 Sep. 2015), pp.254-256, 3 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2015-09-30
Country of Publication
Iraq
No. of Pages
3
Main Subjects
Topics
Abstract EN
Background: Heterocyclic compounds and its derivatives have biological activities and used as analgesic, anti-helminthic, antituberculer, antifungal, antiviral, anticancer and inhibitor of some enzymes.
Oxazepine (benzodiazepine) derivative used in relief of psychoneuroses characterized by anxiety and tension.
Alkaline phosphatase (ALP) hydrolyzes phosphate monoesters, while Lactate dehydrogenase (LDH) catalyses oxidation of L-lactate to pyruvate utilizing NAD+ Objective: The study was carried out to know of the impact of 1,3-oxazepine derivative on the ALP and LDH enzyme activity on human serum in vitro.
Methods: The study included the effect of synthesized 1,3-oxazepine divertive [(Z)-3-(5-mercapto-1-3,4-Thiadizol-2-yl)-2-(4-nitrophenyl)-2,3-dihydro-1,3-oxzepine-4,7-dione] on the activity of enzymes ALP and LDH for (34) healthy Iraqi females serum in vitro.
The activity of both enzymes was measured spectrophotometrically.
Different concentrations of 1,3-oxazepine derivative were used and the inhibition percentage was calculated.
Results: The results of this study revealed that effect of 1,3-oxazepine derivative was inhibitor for ALP and LDH activity and the high inhibition percentage was 87.56% for ALP.
The high inhibition percentage was 50% for LDH when 1,3-oxazepine derivative was used.
Conclusions: 1,3-oxazepine derivative affected as inhibitor on ALP and LDH enzyme activity in human serum in vitro.
This can be used in drug industry in the future.
American Psychological Association (APA)
al-Sadi, Warka T.& al-Tai, Anwar F.& al-Said, Hasan H.& Mahmud, Ali K.. 2015. Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum. Journal of the Faculty of Medicine Baghdad،Vol. 57, no. 3, pp.254-256.
https://search.emarefa.net/detail/BIM-617076
Modern Language Association (MLA)
al-Sadi, Warka T.…[et al.]. Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum. Journal of the Faculty of Medicine Baghdad Vol. 57, no. 3 (2015), pp.254-256.
https://search.emarefa.net/detail/BIM-617076
American Medical Association (AMA)
al-Sadi, Warka T.& al-Tai, Anwar F.& al-Said, Hasan H.& Mahmud, Ali K.. Effect of 1, 3-oxazepine derivative on alkaline phosphatase and lactate dehydrogenase activity in healthy Iraqi females serum. Journal of the Faculty of Medicine Baghdad. 2015. Vol. 57, no. 3, pp.254-256.
https://search.emarefa.net/detail/BIM-617076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 255-256
Record ID
BIM-617076