Copper (II)‎ complexes of anti-inflammatory drugs with nitrogen based ligands : synthesis, characterization and biological activities

العناوين الأخرى

مركبات النحاس ثنائي الشحنة مع أدوية ضد الالتهابات و بعض القواعد النيتروجينية : تحضير، تشخيص و دراسة للفعاليات الحيوية

مقدم أطروحة جامعية

Nasir al-Din, Mutasim Ibrahim

مشرف أطروحة جامعية

Abu Hijlah, Abd al-Latif

أعضاء اللجنة

Abu Ali, Hijazi
Hamid, Mazin

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الكيماء

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2014

الملخص الإنجليزي

Copper(II) complexes of two non-steroidal anti-inflammatory drugs (NSAIDs) naproxen (nap) and salicylate (sal)) with nitrogen donor ligands pyrazole (pz) and metronidazole (mtnd), [Cu(sal)2(pz)2] (1), [Cu(nap)2(pz)4] (2), [Cu2(nap)4(mtnd)2] (3) have been synthesized and spectroscopically characterized.

The crystal structure of complex (1) and (2) has been determined by X-ray crystallography.

In complex 1 the Cu(II) ion is coordinated with two nitrogen of pyrazoles and two oxygens of the salicylate carboxylate groups in copper atom plan and with the other two oxygen atoms of the carboxylate groups at longer distances in the axial sites to yield trans-CuN2O2 + O2 chromophore.

In complex 2 Cu(II) ion is coordinated in the plan with four nitrogen of pyrazoles and the axial sites are occupied by two oxygen of the naproxenato carboxylate groups to yield CuN4+ O2 chromophore.

The catalytic oxidase activities of complexes toward the aerobic oxidations of 3,5-di-tert-butylcatechol (3,5-DTBC) to 3,5-di-tert-butyl-o-benzoquinone (3,5-DTBQ), o-phenylenediamine (OPD) to 2,3-diaminophenazine (DAP), and o-aminophenol (OAP) to 2-amino-3H-phenoxazine-3-one (APX) have been studied.

Solvents-dependent catecholase activity of these complexes solvents: methanol (MeOH), dichloromethane (DCM), and acetonitrile (ACN) also have been studied.

The catalytic activities of these complexes mimic those of copper-containing enzymes catecholase and phenoxazinone synthase.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

91

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-620627