Copper (II) complexes of anti-inflammatory drugs with nitrogen based ligands : synthesis, characterization and biological activities
Other Title(s)
مركبات النحاس ثنائي الشحنة مع أدوية ضد الالتهابات و بعض القواعد النيتروجينية : تحضير، تشخيص و دراسة للفعاليات الحيوية
Dissertant
Thesis advisor
Comitee Members
University
Birzeit University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2014
English Abstract
Copper(II) complexes of two non-steroidal anti-inflammatory drugs (NSAIDs) naproxen (nap) and salicylate (sal)) with nitrogen donor ligands pyrazole (pz) and metronidazole (mtnd), [Cu(sal)2(pz)2] (1), [Cu(nap)2(pz)4] (2), [Cu2(nap)4(mtnd)2] (3) have been synthesized and spectroscopically characterized.
The crystal structure of complex (1) and (2) has been determined by X-ray crystallography.
In complex 1 the Cu(II) ion is coordinated with two nitrogen of pyrazoles and two oxygens of the salicylate carboxylate groups in copper atom plan and with the other two oxygen atoms of the carboxylate groups at longer distances in the axial sites to yield trans-CuN2O2 + O2 chromophore.
In complex 2 Cu(II) ion is coordinated in the plan with four nitrogen of pyrazoles and the axial sites are occupied by two oxygen of the naproxenato carboxylate groups to yield CuN4+ O2 chromophore.
The catalytic oxidase activities of complexes toward the aerobic oxidations of 3,5-di-tert-butylcatechol (3,5-DTBC) to 3,5-di-tert-butyl-o-benzoquinone (3,5-DTBQ), o-phenylenediamine (OPD) to 2,3-diaminophenazine (DAP), and o-aminophenol (OAP) to 2-amino-3H-phenoxazine-3-one (APX) have been studied.
Solvents-dependent catecholase activity of these complexes solvents: methanol (MeOH), dichloromethane (DCM), and acetonitrile (ACN) also have been studied.
The catalytic activities of these complexes mimic those of copper-containing enzymes catecholase and phenoxazinone synthase.
Main Subjects
No. of Pages
91
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental section.
Chapter Three : Results and discussions.
References.
American Psychological Association (APA)
Nasir al-Din, Mutasim Ibrahim. (2014). Copper (II) complexes of anti-inflammatory drugs with nitrogen based ligands : synthesis, characterization and biological activities. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-620627
Modern Language Association (MLA)
Nasir al-Din, Mutasim Ibrahim. Copper (II) complexes of anti-inflammatory drugs with nitrogen based ligands : synthesis, characterization and biological activities. (Master's theses Theses and Dissertations Master). Birzeit University. (2014).
https://search.emarefa.net/detail/BIM-620627
American Medical Association (AMA)
Nasir al-Din, Mutasim Ibrahim. (2014). Copper (II) complexes of anti-inflammatory drugs with nitrogen based ligands : synthesis, characterization and biological activities. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-620627
Language
English
Data Type
Arab Theses
Record ID
BIM-620627
