Effect of dietary protein level on the pharmacokinetic profile of pefloxacin
العناوين الأخرى
تأثير مستوى بروتين العليقة على المسار الدوائي لعقار البيفلوكساسين في الدجاج
المصدر
Kafr El-Sheikh Veterinary Medical Journal
الناشر
جامعة كفر الشيخ كلية الطب البيطري
تاريخ النشر
2003-04-30
دولة النشر
مصر
عدد الصفحات
29
التخصصات الرئيسية
الملخص الإنجليزي
This work was carried out to reveal the effects of different protein levels in diet on serum concentration, pharmacokinetic parameters and tissue residues of pefloxacin.
The bioavailability following intramuscular and oral administration of pefloxacin was determined.
After i.v injection of pefloxacin at a dose of 10 mg/kg b.wt., the drug showed a high serum level (3.79 µg/ml and 3.92 µg/ml) 5 min.
post-injection, for low protein and high protein groups respectively, then the concentration was decreased gradually till reached its minimum level(0.33 and 0.24 µg/ml)for LP and HP groups respectively, at 24 h post-injection.
The present data revealed that the serum concentration time curves of pefloxacin were best described by a two compartment open model following a single intravenous injection of 10 mg/kg b.wt.
Following i.m.
Injection of a single dose of 10 mg/kg b.wt.Pefloxacin , the drug was detected in serum 5 min.
post-injection.
It continued to increase gradually reached its maximum level of 1.89 & 1.77 µg/ml at 1.38 & 1.04 h for LP & HP groups respectively.
The systemic bioavailability of pefloxacin following its i.m.
Injection in a dose of 10 mg/kg b.wt.
was 69.77% for LP group and 78.18% for HP group.
Following oral administration of pefloxacin at a single dose of 10 mg/kg b.wt,the drug was detected in serum 10 min.post-administration and it continued to increase gradually reached its maximum level at 3.10 & 2.03 h, for LP & HP groups respectively.The systemic bioavailability of pefloxacin following its oral administration.
were 62.15% & 58.61% for LP & HP groups respectively.
The
نوع البيانات
أوراق مؤتمرات
رقم السجل
BIM-628367
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Aziz, M. I.& Abu Zahrah, Abu al-Nasrah& al-Zughbi, Amal Fathi. 2003-04-30. Effect of dietary protein level on the pharmacokinetic profile of pefloxacin. Scientific Congress of the Faculty of Veterinary Medicine (1st : 2003 : Kafr El-Sheikh, Egypt). . Vol. 1, no. 1 (2003), pp.549-577.Kafr El-Sheikh Egypt : Kafr El-Sheikh University Faculty of Veterinary Medicine.
https://search.emarefa.net/detail/BIM-628367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Aziz, M. I.…[et al.]. Effect of dietary protein level on the pharmacokinetic profile of pefloxacin. . Kafr El-Sheikh Egypt : Kafr El-Sheikh University Faculty of Veterinary Medicine. 2003-04-30.
https://search.emarefa.net/detail/BIM-628367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Aziz, M. I.& Abu Zahrah, Abu al-Nasrah& al-Zughbi, Amal Fathi. Effect of dietary protein level on the pharmacokinetic profile of pefloxacin. . Scientific Congress of the Faculty of Veterinary Medicine (1st : 2003 : Kafr El-Sheikh, Egypt).
https://search.emarefa.net/detail/BIM-628367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر