Construction of new cimetidine selective electrodes for determination cimetidine in pharmaceutical drugs

الملخص EN

Cimetidine selective electrodes were constructed based on cimetidine -phosphotungstate (EMB-PT) complex with different plasticizers; di-butyl phosphate (DBP), tri-butyl phosphate (TBP), di-butyl phthalate (DBPH), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH).

The electrodes based on DBP, TBP and DOPH plasticizers gave Narnistain slope which are 56.65,56.5 and 58.5 mV/decade.

For the electrodes basedes on DOPH the concentration range was (10-5to 10-2 )M , with detection limit of 1.9x10-6 M and pH range 4.36 – 6.70 .The electrodes based on DBPH and NPOE showed non-Nernistain slopes, 40.6 mV/decade for both plasticizers.

Interfering of some cations was investigated and shows no interfering with electrodes response.

Potentiometric methods were used for measuring cimetidine in pharmaceutical drugs (tablets) and the electrode based on DOPH was used for determination.

The recovery obtained from measuring was in good agreements with that given in British Pharmacopeias.