Construction of new cimetidine selective electrodes for determination cimetidine in pharmaceutical drugs
Joint Authors
Husayn, Lamya
Ahmad, Adi
Muayyad, Marwah
Sayhud, Suhaylah Kazim
Husayn, Janan
Source
Journal of Kufa for Chemical Science
Issue
Vol. 2012, Issue 6 (31 Dec. 2012), pp.57-66, 10 p.
Publisher
University of Kufa Faculty of Education for Women Department of Chemistry
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract AR
في هذه الدراسة حضرت أقطاب انتفائية لمادة ا السمتيدن الدوائية معتمدة على معقد الدواء مع dodeca-Tungstophoric acid مع مجموعة من المواد الملدن Tri-buty1 phosphate (TBP), di-buty1 phthalate di-buty1 phosphate (DBP), (DBPH), (NPOE) o-pheny1 octyl ether, و di octy1 phthalate (DOPH)-.
أظهرت الأقطاب مع الملدنات DBP، TBP، DOPH انحدر 56..5، 56.6، Mv / decade 58.على التوالي.
أظهر القطب المعتمد على DOPH كملدن مدى تركيز خطي 1021-10-5 مولاري و مدى دالة حامضية 6.70-4.36.
أما الأقطاب للملدنات DBPH، NPOE أظهرت استجابة غير نرنستية بانحدار 40.5 Mv / decade.
أظهرت الدراسة عدم وجود تداخل لعدد من الايونات الموجبة الآحادية مثل +Li+, Na+, K و الثنائية مثل , +Mg2+, Ca2 +Zn2 و الثلاثية مثلAl3+, Cr3+Fe3+, و.
تم تطبيق هذا القطب على المستحضرات الصيدلانية باستخدام قطب المستند على DOPH كملدن و قد أعطت نتائج جيدة.
Abstract EN
Cimetidine selective electrodes were constructed based on cimetidine -phosphotungstate (EMB-PT) complex with different plasticizers; di-butyl phosphate (DBP), tri-butyl phosphate (TBP), di-butyl phthalate (DBPH), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH).
The electrodes based on DBP, TBP and DOPH plasticizers gave Narnistain slope which are 56.65,56.5 and 58.5 mV/decade.
For the electrodes basedes on DOPH the concentration range was (10-5to 10-2 )M , with detection limit of 1.9x10-6 M and pH range 4.36 – 6.70 .The electrodes based on DBPH and NPOE showed non-Nernistain slopes, 40.6 mV/decade for both plasticizers.
Interfering of some cations was investigated and shows no interfering with electrodes response.
Potentiometric methods were used for measuring cimetidine in pharmaceutical drugs (tablets) and the electrode based on DOPH was used for determination.
The recovery obtained from measuring was in good agreements with that given in British Pharmacopeias.
American Psychological Association (APA)
Sayhud, Suhaylah Kazim& Husayn, Janan& Husayn, Lamya& Ahmad, Adi& Muayyad, Marwah. 2012. Construction of new cimetidine selective electrodes for determination cimetidine in pharmaceutical drugs. Journal of Kufa for Chemical Science،Vol. 2012, no. 6, pp.57-66.
https://search.emarefa.net/detail/BIM-642579
Modern Language Association (MLA)
Husayn, Janan…[et al.]. Construction of new cimetidine selective electrodes for determination cimetidine in pharmaceutical drugs. Journal of Kufa for Chemical Science No. 6 (Dec. 2012), pp.57-66.
https://search.emarefa.net/detail/BIM-642579
American Medical Association (AMA)
Sayhud, Suhaylah Kazim& Husayn, Janan& Husayn, Lamya& Ahmad, Adi& Muayyad, Marwah. Construction of new cimetidine selective electrodes for determination cimetidine in pharmaceutical drugs. Journal of Kufa for Chemical Science. 2012. Vol. 2012, no. 6, pp.57-66.
https://search.emarefa.net/detail/BIM-642579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65-66
Record ID
BIM-642579
