A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions
المؤلفون المشاركون
Park, Seung-Chun
Lee, Seung Jin
Husayn, M. D. Aqil
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 23، العدد 1 (31 يناير/كانون الثاني 2016)، ص ص. 9-14، 6ص.
الناشر
تاريخ النشر
2016-01-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Postinflammatory hyperpigmentation (PIH) is an acquire hypermelanosis after cutaneous inflammation and injury.
The aim of the present study was to investigate a natural ingredient with the anti-inflammatory and depigmentation activities into possible applications of postinflammatory hyperpigmentation.
Methanol extracts of Lespedeza bicolor and its various fractions inhibited LPS-induced NO production in RAW 264.7 macrophages in a concentration-dependent manner.
In particular, the ethyl acetate fraction was shown to be inhibition of NO production (89 %) and down-regulation of iNOS mRNA without causing cytotoxicity.
In addition, ethyl acetate fraction significantly attenuated LPS-induced NF-jB activation (P < 0.05), indicating the antiinflammatory activity due to NF-jB inhibition.
Moreover, extracts, mainly ethyl acetate fraction, exhibited not only DPPH free radical scavenging activity (IC50, 112.45 lg / mL) with 4 times lower activity than ascorbic acid, but also anti-tyrosinase activity (IC50, 1 lg / mL) with a similar activity to arbutin showing a competitive inhibitor.
Furthermore, vitexin and haginins A, B and C were identified through LC–MS analysis as potential compounds responsible for these effects.
These results suggest that L.
bicolor extract have anti-inflammatory, antioxidant activities and tyrosinase inhibitory effect and it might be used in the management of postinflammatory pigmentation through inhibition of pathogenic process involved in hyperpigmentation.
ª 2015 The Authors.
Production and hosting by Elsevier B.V.
on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses / by-nc-nd /4.0/).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Seung Jin& Husayn, M. D. Aqil& Park, Seung-Chun. 2016. A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions. Saudi Journal of Biological Sciences،Vol. 23, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-652261
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Seung-Chun…[et al.]. A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions. Saudi Journal of Biological Sciences Vol. 23, no. 1 (Jan. 2016), pp.9-14.
https://search.emarefa.net/detail/BIM-652261
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Seung Jin& Husayn, M. D. Aqil& Park, Seung-Chun. A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-652261
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 14
رقم السجل
BIM-652261
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر