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A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions
Joint Authors
Park, Seung-Chun
Lee, Seung Jin
Husayn, M. D. Aqil
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 1 (31 Jan. 2016), pp.9-14, 6 p.
Publisher
Publication Date
2016-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Postinflammatory hyperpigmentation (PIH) is an acquire hypermelanosis after cutaneous inflammation and injury.
The aim of the present study was to investigate a natural ingredient with the anti-inflammatory and depigmentation activities into possible applications of postinflammatory hyperpigmentation.
Methanol extracts of Lespedeza bicolor and its various fractions inhibited LPS-induced NO production in RAW 264.7 macrophages in a concentration-dependent manner.
In particular, the ethyl acetate fraction was shown to be inhibition of NO production (89 %) and down-regulation of iNOS mRNA without causing cytotoxicity.
In addition, ethyl acetate fraction significantly attenuated LPS-induced NF-jB activation (P < 0.05), indicating the antiinflammatory activity due to NF-jB inhibition.
Moreover, extracts, mainly ethyl acetate fraction, exhibited not only DPPH free radical scavenging activity (IC50, 112.45 lg / mL) with 4 times lower activity than ascorbic acid, but also anti-tyrosinase activity (IC50, 1 lg / mL) with a similar activity to arbutin showing a competitive inhibitor.
Furthermore, vitexin and haginins A, B and C were identified through LC–MS analysis as potential compounds responsible for these effects.
These results suggest that L.
bicolor extract have anti-inflammatory, antioxidant activities and tyrosinase inhibitory effect and it might be used in the management of postinflammatory pigmentation through inhibition of pathogenic process involved in hyperpigmentation.
ª 2015 The Authors.
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on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses / by-nc-nd /4.0/).
American Psychological Association (APA)
Lee, Seung Jin& Husayn, M. D. Aqil& Park, Seung-Chun. 2016. A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions. Saudi Journal of Biological Sciences،Vol. 23, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-652261
Modern Language Association (MLA)
Lee, Seung Jin…[et al.]. A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions. Saudi Journal of Biological Sciences Vol. 23, no. 1 (Jan. 2016), pp.9-14.
https://search.emarefa.net/detail/BIM-652261
American Medical Association (AMA)
Lee, Seung Jin& Husayn, M. D. Aqil& Park, Seung-Chun. A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-652261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14
Record ID
BIM-652261