The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery

المؤلفون المشاركون

Khayri, Marwah A.
Abd al-Latif, Mustafa K.
Mabud, Hani A.

المصدر

Ain Shams Journal of Anesthesiology

العدد

المجلد 7، العدد 3 (31 ديسمبر/كانون الأول 2014)، ص ص. 362-366، 5ص.

الناشر

جامعة عين شمس كلية الطب قسم التخدير

تاريخ النشر

2014-12-31

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Background Myocardial ischemia/reperfusion (IR) injury is a complex phenomenon that leads to organ dysfunction and failure after coronary artery bypass graft surgery (CABG).

Data from numerous animal experiments and clinical trials suggest that magnesium, a physiological calcium blocker, may be effi cacious for the reduction in reperfusion injury.

We investigated whether an intravenous administration of magnesium before reperfusion can decrease IR injury after CABG with cardiopulmonary bypass.

Patients and methods A total of 40 patients undergoing CABG were randomly assigned to a MG group (n = 20) or an NS group (n = 20).

The patients in the MG group were administered 25 mg/kg of MgSO4 mixed in 100 ml normal saline intravenously before reperfusion, and patients in the NS group were administered an equal volume of normal saline.

The levels of lactate and pH were measured to assess reperfusion injury at three specifi c times, which were before induction and after declamping by 10 min and 30 min.

To evaluate postoperative other organ dysfunction, alanine aminotransferase and creatinine levels were measured at postoperative day 0.

Results The blood lactate levels were signifi cantly lower at 10 and 30 min after reperfusion in the MG group compared with the NS group.

In addition, postoperative alanine aminotransferase was signifi cantly higher in the NS group than in the MG group.

Conclusion Magnesium administration before reperfusion of the heart in CABG with cardiopulmonary bypass signifi cantly reduces blood lactate levels.

These fi ndings suggest that magnesium treatment may have protective effects on IR injury.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Abd al-Latif, Mustafa K.& Khayri, Marwah A.& Mabud, Hani A.. 2014. The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery. Ain Shams Journal of Anesthesiology،Vol. 7, no. 3, pp.362-366.
https://search.emarefa.net/detail/BIM-652294

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Abd al-Latif, Mustafa K.…[et al.]. The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery. Ain Shams Journal of Anesthesiology Vol. 7, no. 3 (Sep. / Dec. 2014), pp.362-366.
https://search.emarefa.net/detail/BIM-652294

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Abd al-Latif, Mustafa K.& Khayri, Marwah A.& Mabud, Hani A.. The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery. Ain Shams Journal of Anesthesiology. 2014. Vol. 7, no. 3, pp.362-366.
https://search.emarefa.net/detail/BIM-652294

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 366

رقم السجل

BIM-652294