The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery
Joint Authors
Khayri, Marwah A.
Abd al-Latif, Mustafa K.
Mabud, Hani A.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 7, Issue 3 (31 Dec. 2014), pp.362-366, 5 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background Myocardial ischemia/reperfusion (IR) injury is a complex phenomenon that leads to organ dysfunction and failure after coronary artery bypass graft surgery (CABG).
Data from numerous animal experiments and clinical trials suggest that magnesium, a physiological calcium blocker, may be effi cacious for the reduction in reperfusion injury.
We investigated whether an intravenous administration of magnesium before reperfusion can decrease IR injury after CABG with cardiopulmonary bypass.
Patients and methods A total of 40 patients undergoing CABG were randomly assigned to a MG group (n = 20) or an NS group (n = 20).
The patients in the MG group were administered 25 mg/kg of MgSO4 mixed in 100 ml normal saline intravenously before reperfusion, and patients in the NS group were administered an equal volume of normal saline.
The levels of lactate and pH were measured to assess reperfusion injury at three specifi c times, which were before induction and after declamping by 10 min and 30 min.
To evaluate postoperative other organ dysfunction, alanine aminotransferase and creatinine levels were measured at postoperative day 0.
Results The blood lactate levels were signifi cantly lower at 10 and 30 min after reperfusion in the MG group compared with the NS group.
In addition, postoperative alanine aminotransferase was signifi cantly higher in the NS group than in the MG group.
Conclusion Magnesium administration before reperfusion of the heart in CABG with cardiopulmonary bypass signifi cantly reduces blood lactate levels.
These fi ndings suggest that magnesium treatment may have protective effects on IR injury.
American Psychological Association (APA)
Abd al-Latif, Mustafa K.& Khayri, Marwah A.& Mabud, Hani A.. 2014. The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery. Ain Shams Journal of Anesthesiology،Vol. 7, no. 3, pp.362-366.
https://search.emarefa.net/detail/BIM-652294
Modern Language Association (MLA)
Abd al-Latif, Mustafa K.…[et al.]. The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery. Ain Shams Journal of Anesthesiology Vol. 7, no. 3 (Sep. / Dec. 2014), pp.362-366.
https://search.emarefa.net/detail/BIM-652294
American Medical Association (AMA)
Abd al-Latif, Mustafa K.& Khayri, Marwah A.& Mabud, Hani A.. The effects of magnesium sulfate pretreatment on reperfusion injury after coronary artery bypass graft surgery. Ain Shams Journal of Anesthesiology. 2014. Vol. 7, no. 3, pp.362-366.
https://search.emarefa.net/detail/BIM-652294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 366
Record ID
BIM-652294