Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP)
المؤلفون المشاركون
Jaradat, Ahmad A.
Sharif, Khalid Abd Allah
Mahmud, Naim Ahmad
المصدر
العدد
المجلد 37، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 230-233، 4ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
البحرين
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
To assess the efficacy of low-dose prednisolone in patients with ITP.
Design: A Prospective Randomized Controlled Trial.
Setting: Salmaniya Medical Complex, Kingdom of Bahrain.
Method: A randomized controlled trial was conducted comparing the conventional-dose to a lowdose of prednisolone (0.25 mg/kg/day).
Forty-one patients with ITP were enrolled in the study; 21 patients were randomized to low-dose prednisolone (group I) and 20 patients received the conventional-dose (group II).
Result: The overall remission rate (OR) for both groups was 78.05%.
There was no statistically significant difference between both groups in terms of group overall remission 17 (81%) versus 15 (75%), group complete remission 11 (52.4%) versus 10 (50%) or partial remission rate 6 (28.6%) versus 6 (25%).
In addition, failure rate, relapse rate, and splenectomy rate were similar and not statistically significant.
Two (10%) patients developed complications related to steroids therapy, both were in group II, but were not statistically significant.
Conclusion: Although the study had a small number of patients, it revealed that low-dose of prednisolone (0.25 mg/kg/day) is as effective as the conventional-dose (1 mg/kg/day) and probably, safer.
Accordingly, we recommend the use of low-dose prednisolone as initial therapy for ITP rather than the high-dose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharif, Khalid Abd Allah& Mahmud, Naim Ahmad& Jaradat, Ahmad A.. 2015. Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP). Bahrain Medical Bulletin،Vol. 37, no. 4, pp.230-233.
https://search.emarefa.net/detail/BIM-654406
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharif, Khalid Abd Allah…[et al.]. Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP). Bahrain Medical Bulletin Vol. 37, no. 4 (Dec. 2015), pp.230-233.
https://search.emarefa.net/detail/BIM-654406
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharif, Khalid Abd Allah& Mahmud, Naim Ahmad& Jaradat, Ahmad A.. Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP). Bahrain Medical Bulletin. 2015. Vol. 37, no. 4, pp.230-233.
https://search.emarefa.net/detail/BIM-654406
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 232-233
رقم السجل
BIM-654406
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر