Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP)
Joint Authors
Jaradat, Ahmad A.
Sharif, Khalid Abd Allah
Mahmud, Naim Ahmad
Source
Issue
Vol. 37, Issue 4 (31 Dec. 2015), pp.230-233, 4 p.
Publisher
King Hamad University Hospital
Publication Date
2015-12-31
Country of Publication
Bahrain
No. of Pages
4
Main Subjects
Topics
Abstract EN
To assess the efficacy of low-dose prednisolone in patients with ITP.
Design: A Prospective Randomized Controlled Trial.
Setting: Salmaniya Medical Complex, Kingdom of Bahrain.
Method: A randomized controlled trial was conducted comparing the conventional-dose to a lowdose of prednisolone (0.25 mg/kg/day).
Forty-one patients with ITP were enrolled in the study; 21 patients were randomized to low-dose prednisolone (group I) and 20 patients received the conventional-dose (group II).
Result: The overall remission rate (OR) for both groups was 78.05%.
There was no statistically significant difference between both groups in terms of group overall remission 17 (81%) versus 15 (75%), group complete remission 11 (52.4%) versus 10 (50%) or partial remission rate 6 (28.6%) versus 6 (25%).
In addition, failure rate, relapse rate, and splenectomy rate were similar and not statistically significant.
Two (10%) patients developed complications related to steroids therapy, both were in group II, but were not statistically significant.
Conclusion: Although the study had a small number of patients, it revealed that low-dose of prednisolone (0.25 mg/kg/day) is as effective as the conventional-dose (1 mg/kg/day) and probably, safer.
Accordingly, we recommend the use of low-dose prednisolone as initial therapy for ITP rather than the high-dose.
American Psychological Association (APA)
Sharif, Khalid Abd Allah& Mahmud, Naim Ahmad& Jaradat, Ahmad A.. 2015. Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP). Bahrain Medical Bulletin،Vol. 37, no. 4, pp.230-233.
https://search.emarefa.net/detail/BIM-654406
Modern Language Association (MLA)
Sharif, Khalid Abd Allah…[et al.]. Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP). Bahrain Medical Bulletin Vol. 37, no. 4 (Dec. 2015), pp.230-233.
https://search.emarefa.net/detail/BIM-654406
American Medical Association (AMA)
Sharif, Khalid Abd Allah& Mahmud, Naim Ahmad& Jaradat, Ahmad A.. Comparison of low-dose versus conventional-dose prednisolone in the treatment of idiopathic thrombocytopenic purpura (ITP). Bahrain Medical Bulletin. 2015. Vol. 37, no. 4, pp.230-233.
https://search.emarefa.net/detail/BIM-654406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 232-233
Record ID
BIM-654406