![](/images/graphics-bg.png)
Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study
المؤلفون المشاركون
Ghossain, Antoine
Akoum, Riyad
Abd Allah, Eddie K.
Sad, Mishal
Awdah, Adnan
Abi Aad, Fuad
Bajjani, Nuha
Brihi, Imil
Audi, Akram
المصدر
العدد
المجلد 63، العدد 4 (31 ديسمبر/كانون الأول 2015)، ص ص. 271-278، 8ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
لبنان
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Inflammatory local recurrence (ILR) after breast-conserving surgery for noninflammatory breast cancer (BC) is associated with dismal prognosis.
Risk factors for ILR are not well defined.
Methods: Between 2001 and 2010, twelve patients at our hospital developed ILR after breast-conserving surgery, adjuvant chemotherapy, and radiotherapy for BC.
We compared their clinico-pathological characteristics to those of 24 patients with noninflammatory local recurrence (non-ILR), 24 patients with distant metastases, and 48 disease-free controls, matched for age and observation period.
Results: The median time to ILR was 10 months.
In univariate analysis, extent of lymph node involvement (p < 0.05), multifocality (p < 0.05), c-erbB2 overexpression (p < 0.05), and lymphovascular invasion (LVI) (p < 0.001) affected the risk of ILR.
Conditional logistic regression analysis showed a significant association between ILR and combined LVI and high histopathological grade.
The odds ratio (OR) for ILR versus non-ILR was 6.14 (95% confidence interval [CI] 1.48-25.38) and for ILR versus distant metastases it was 3.05 (95% CI 0.09-97.83) when both LVI and high histopathological grade were present.
Patients with family history of BC were more likely to present with ILR than non-ILR (OR 5.47; 95% CI 1.55-19.31) or distant relapse (OR 5.62; 95% CI 0.26-119.95).
Conclusions: Pre- and postmenopausal women with high-grade BC and LVI are at increased risk to develop ILR, especially in the presence of family history of BC.
Identification of risk factors for this lethal form of recurrent BC may lead to more effective preventive treatment strategies in properly selected patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akoum, Riyad& Abd Allah, Eddie K.& Sad, Mishal& Awdah, Adnan& Abi Aad, Fuad& Bajjani, Nuha…[et al.]. 2015. Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study. Journal Médical Libanais،Vol. 63, no. 4, pp.271-278.
https://search.emarefa.net/detail/BIM-655069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akoum, Riyad…[et al.]. Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study. Journal Médical Libanais Vol. 63, no. 4 (Oct. / Dec. 2015), pp.271-278.
https://search.emarefa.net/detail/BIM-655069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akoum, Riyad& Abd Allah, Eddie K.& Sad, Mishal& Awdah, Adnan& Abi Aad, Fuad& Bajjani, Nuha…[et al.]. Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study. Journal Médical Libanais. 2015. Vol. 63, no. 4, pp.271-278.
https://search.emarefa.net/detail/BIM-655069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 177-178
رقم السجل
BIM-655069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)