Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study
Joint Authors
Ghossain, Antoine
Akoum, Riyad
Abd Allah, Eddie K.
Sad, Mishal
Awdah, Adnan
Abi Aad, Fuad
Bajjani, Nuha
Brihi, Imil
Audi, Akram
Source
Issue
Vol. 63, Issue 4 (31 Dec. 2015), pp.271-278, 8 p.
Publisher
Publication Date
2015-12-31
Country of Publication
Lebanon
No. of Pages
8
Main Subjects
Topics
Abstract EN
Inflammatory local recurrence (ILR) after breast-conserving surgery for noninflammatory breast cancer (BC) is associated with dismal prognosis.
Risk factors for ILR are not well defined.
Methods: Between 2001 and 2010, twelve patients at our hospital developed ILR after breast-conserving surgery, adjuvant chemotherapy, and radiotherapy for BC.
We compared their clinico-pathological characteristics to those of 24 patients with noninflammatory local recurrence (non-ILR), 24 patients with distant metastases, and 48 disease-free controls, matched for age and observation period.
Results: The median time to ILR was 10 months.
In univariate analysis, extent of lymph node involvement (p < 0.05), multifocality (p < 0.05), c-erbB2 overexpression (p < 0.05), and lymphovascular invasion (LVI) (p < 0.001) affected the risk of ILR.
Conditional logistic regression analysis showed a significant association between ILR and combined LVI and high histopathological grade.
The odds ratio (OR) for ILR versus non-ILR was 6.14 (95% confidence interval [CI] 1.48-25.38) and for ILR versus distant metastases it was 3.05 (95% CI 0.09-97.83) when both LVI and high histopathological grade were present.
Patients with family history of BC were more likely to present with ILR than non-ILR (OR 5.47; 95% CI 1.55-19.31) or distant relapse (OR 5.62; 95% CI 0.26-119.95).
Conclusions: Pre- and postmenopausal women with high-grade BC and LVI are at increased risk to develop ILR, especially in the presence of family history of BC.
Identification of risk factors for this lethal form of recurrent BC may lead to more effective preventive treatment strategies in properly selected patients.
American Psychological Association (APA)
Akoum, Riyad& Abd Allah, Eddie K.& Sad, Mishal& Awdah, Adnan& Abi Aad, Fuad& Bajjani, Nuha…[et al.]. 2015. Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study. Journal Médical Libanais،Vol. 63, no. 4, pp.271-278.
https://search.emarefa.net/detail/BIM-655069
Modern Language Association (MLA)
Akoum, Riyad…[et al.]. Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study. Journal Médical Libanais Vol. 63, no. 4 (Oct. / Dec. 2015), pp.271-278.
https://search.emarefa.net/detail/BIM-655069
American Medical Association (AMA)
Akoum, Riyad& Abd Allah, Eddie K.& Sad, Mishal& Awdah, Adnan& Abi Aad, Fuad& Bajjani, Nuha…[et al.]. Predictors of inflammatory localrecurrence after breast-conserving therapy for breast cancer : matched case-control study. Journal Médical Libanais. 2015. Vol. 63, no. 4, pp.271-278.
https://search.emarefa.net/detail/BIM-655069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 177-178
Record ID
BIM-655069