The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism
المؤلفون المشاركون
Torun, Dilek
Yildiz, Ismail
Micozkadioglu, Hasan
Nursal, Gul Nahhal
Yigit, Fatimah
Ozelsancak, Ruya
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 27، العدد 1 (29 فبراير/شباط 2016)، ص ص. 15-22، 8ص.
الناشر
تاريخ النشر
2016-02-29
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
- المرضى
- الغدة الجار درقية
- العظام
- الأيض
- الكالسيوم
- فرط نشاط جارات الدرقية
- الأنسجة الضامة
- علم المداواة
- غسيل الكلى
- الدم
- فقر الدم
الملخص EN
The aim of this study was to investigate the effects of cinacalcet therapy on anemia parameters, bone mineral metabolism, left ventricular mass index (LVMI) and parathyroid gland volume in hemodialysis (HD) patients with secondary hyperparathyroidism.
Twenty-five HD patients (M/F: 11 / 14, mean age: 45.2 ± 17.9 years, mean HD duration: 96.4 ± 32.7 months) were included in this prospective pilot study.
The indication to start calcimimetic therapy was persistent serum levels of parathyroid hormone (PTH) >1000 pg / mL, refractory to intravenous (i.v.) vitamin D and phosphate-binding therapy.
The initial and one-year results of adjusted serum calcium (Ca+2), phosphate (P), Ca × P product, PTH, hemoglobin (Hb) and ferritin levels, transferrin saturation index (TSAT), median weekly erythropoietin (EPO) dose, LVMI, and parathyroid volume by parathyroid ultrasonography were determined.
There were no differences between pre- and posttreatment levels of serum Ca+2 (P = 0.853), P (P = 0.447), Ca × P product (P = 0.587), PTH (P = 0.273), ferritin (P = 0.153) and TSAT (P = 0.104).
After 1 year of calcimimetic therapy, the Hb levels were significantly higher than the initial levels (P = 0.048).
The weekly dose of EPO decreased with no statistical significance.
The dose of cinacalcet was increased from 32.4 ± 12.0 to 60.0 ± 24.4 mg/day (P = 0.01).
There were no differences between the pre- and post-treatment results regarding weekly vitamin D dose, parenteral iron dose, LVMI and parathyroid volume.
The results of our study suggest that cinacalcet therapy might have an additional benefit in the control anemia in HD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Torun, Dilek& Yildiz, Ismail& Micozkadioglu, Hasan& Nursal, Gul Nahhal& Yigit, Fatimah& Ozelsancak, Ruya. 2016. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-655776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Torun, Dilek…[et al.]. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 1 (Jan. / Feb. 2016), pp.15-22.
https://search.emarefa.net/detail/BIM-655776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Torun, Dilek& Yildiz, Ismail& Micozkadioglu, Hasan& Nursal, Gul Nahhal& Yigit, Fatimah& Ozelsancak, Ruya. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-655776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 20-22
رقم السجل
BIM-655776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر