The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism
Joint Authors
Torun, Dilek
Yildiz, Ismail
Micozkadioglu, Hasan
Nursal, Gul Nahhal
Yigit, Fatimah
Ozelsancak, Ruya
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 1 (29 Feb. 2016), pp.15-22, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-02-29
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
- Patients
- الغدة الجار درقية
- Bones
- Metabolism
- Calcium
- Hyperparathyroidism
- Connective tissues
- Therapeutics
- Hemodialysis
- Blood
- Anemia
Abstract EN
The aim of this study was to investigate the effects of cinacalcet therapy on anemia parameters, bone mineral metabolism, left ventricular mass index (LVMI) and parathyroid gland volume in hemodialysis (HD) patients with secondary hyperparathyroidism.
Twenty-five HD patients (M/F: 11 / 14, mean age: 45.2 ± 17.9 years, mean HD duration: 96.4 ± 32.7 months) were included in this prospective pilot study.
The indication to start calcimimetic therapy was persistent serum levels of parathyroid hormone (PTH) >1000 pg / mL, refractory to intravenous (i.v.) vitamin D and phosphate-binding therapy.
The initial and one-year results of adjusted serum calcium (Ca+2), phosphate (P), Ca × P product, PTH, hemoglobin (Hb) and ferritin levels, transferrin saturation index (TSAT), median weekly erythropoietin (EPO) dose, LVMI, and parathyroid volume by parathyroid ultrasonography were determined.
There were no differences between pre- and posttreatment levels of serum Ca+2 (P = 0.853), P (P = 0.447), Ca × P product (P = 0.587), PTH (P = 0.273), ferritin (P = 0.153) and TSAT (P = 0.104).
After 1 year of calcimimetic therapy, the Hb levels were significantly higher than the initial levels (P = 0.048).
The weekly dose of EPO decreased with no statistical significance.
The dose of cinacalcet was increased from 32.4 ± 12.0 to 60.0 ± 24.4 mg/day (P = 0.01).
There were no differences between the pre- and post-treatment results regarding weekly vitamin D dose, parenteral iron dose, LVMI and parathyroid volume.
The results of our study suggest that cinacalcet therapy might have an additional benefit in the control anemia in HD patients.
American Psychological Association (APA)
Torun, Dilek& Yildiz, Ismail& Micozkadioglu, Hasan& Nursal, Gul Nahhal& Yigit, Fatimah& Ozelsancak, Ruya. 2016. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-655776
Modern Language Association (MLA)
Torun, Dilek…[et al.]. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 1 (Jan. / Feb. 2016), pp.15-22.
https://search.emarefa.net/detail/BIM-655776
American Medical Association (AMA)
Torun, Dilek& Yildiz, Ismail& Micozkadioglu, Hasan& Nursal, Gul Nahhal& Yigit, Fatimah& Ozelsancak, Ruya. The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 1, pp.15-22.
https://search.emarefa.net/detail/BIM-655776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 20-22
Record ID
BIM-655776