Immunohistochemical expression of hypoxia-inducible factor-1α in triple negative breast cancer

الملخص EN

Triple-negative breast cancer is a malignant neoplasm characterized by absent expression of estrogen, progesterone and human epidermal growth factor-2 receptors.

Hypoxia-inducible factor-1 alpha is up-regulated under hypoxia and associated with induction of angiogenesis resulting in proliferation, aggressive tumor phenotype and metastasis.

Determination of the potential role of Hypoxia-inducible factor-1 alpha in the development and conventional clinicopathologic factors, and to demonstrate their prognostic relevance in Triple-negative breast cancer.

A pro and retrospective study of 281 female patients with breast cancer.

The fifty four triple-negative breast cancer formalin-fixed, paraffin-embedded Specimenspresented from all cases were immuno-stained by Hypoxia-inducible factor-1 alpha Immunohistochemical marker.

The age groups distributed from 23-85 years old, mean age 51.23±11.26 years.

Overall cases, triple negative breast cancer presented in 19.2%; most frequently younger,grade III, tumor size ≥ 2 cm, and positive lymph node metastasis or recurrent more than other subtypes.

Hypoxia-inducible factor-1 alpha expression was strongly associated and significantly differentwith grade (p = 0.001) ,lymph node metastasis (p<0.001) and Ki-67 expression (p = 0.003).

Detected Hypoxia-inducible factor-1 alpha expression has an important role in pathogenesis, drug resistance and in uncontrolled proliferation cells or as important conductor of the worst prognosis in triple negative-breast cancer.