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Immunohistochemical expression of hypoxia-inducible factor-1α in triple negative breast cancer
Other Title(s)
التعابير المناعية النسيجية الكيميائية للعامل المحرض على نقص الأكسدة-1 ألفا في سرطان الثدي ثلاثي السلبية
Joint Authors
Ali, Mahdi Jasim Muhammad
Hassun, Abbas Fadil
al-Khafaji, Haydar Abd al-Rida
Source
Issue
Vol. 12, Issue 4 (31 Dec. 2015), pp.902-915, 14 p.
Publisher
University of Babylon College of Medicine
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Abstract EN
Triple-negative breast cancer is a malignant neoplasm characterized by absent expression of estrogen, progesterone and human epidermal growth factor-2 receptors.
Hypoxia-inducible factor-1 alpha is up-regulated under hypoxia and associated with induction of angiogenesis resulting in proliferation, aggressive tumor phenotype and metastasis.
Determination of the potential role of Hypoxia-inducible factor-1 alpha in the development and conventional clinicopathologic factors, and to demonstrate their prognostic relevance in Triple-negative breast cancer.
A pro and retrospective study of 281 female patients with breast cancer.
The fifty four triple-negative breast cancer formalin-fixed, paraffin-embedded Specimenspresented from all cases were immuno-stained by Hypoxia-inducible factor-1 alpha Immunohistochemical marker.
The age groups distributed from 23-85 years old, mean age 51.23±11.26 years.
Overall cases, triple negative breast cancer presented in 19.2%; most frequently younger,grade III, tumor size ≥ 2 cm, and positive lymph node metastasis or recurrent more than other subtypes.
Hypoxia-inducible factor-1 alpha expression was strongly associated and significantly differentwith grade (p = 0.001) ,lymph node metastasis (p<0.001) and Ki-67 expression (p = 0.003).
Detected Hypoxia-inducible factor-1 alpha expression has an important role in pathogenesis, drug resistance and in uncontrolled proliferation cells or as important conductor of the worst prognosis in triple negative-breast cancer.
American Psychological Association (APA)
Ali, Mahdi Jasim Muhammad& al-Khafaji, Haydar Abd al-Rida& Hassun, Abbas Fadil. 2015. Immunohistochemical expression of hypoxia-inducible factor-1α in triple negative breast cancer. Medical Journal of Babylon،Vol. 12, no. 4, pp.902-915.
https://search.emarefa.net/detail/BIM-656377
Modern Language Association (MLA)
Ali, Mahdi Jasim Muhammad…[et al.]. Immunohistochemical expression of hypoxia-inducible factor-1α in triple negative breast cancer. Medical Journal of Babylon Vol. 12, no. 4 (2015), pp.902-915.
https://search.emarefa.net/detail/BIM-656377
American Medical Association (AMA)
Ali, Mahdi Jasim Muhammad& al-Khafaji, Haydar Abd al-Rida& Hassun, Abbas Fadil. Immunohistochemical expression of hypoxia-inducible factor-1α in triple negative breast cancer. Medical Journal of Babylon. 2015. Vol. 12, no. 4, pp.902-915.
https://search.emarefa.net/detail/BIM-656377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 912-915
Record ID
BIM-656377