Detection and prevalence of inducible clindamycin resistance in clinical and nasal carriage Staphylococcus aureus isolates in Jordan

العناوين الأخرى

كشف و انتشار بكتريا المكورات العنقودية المحفزة لمقاومة الكليندامايسين من عينات مرضيه و أنفية ناقلة لها في الأردن

مقدم أطروحة جامعية

al-Jarajirah, Dua Abd al-Karim

مشرف أطروحة جامعية

al-Zaraini, Wail Ali

أعضاء اللجنة

al-Shakanbah, Jumah Muti
al-Tarawinah, Khalid Ahmad
Khulayfat, Khalid

الجامعة

جامعة مؤتة

الكلية

كلية العلوم

القسم الأكاديمي

قسم الأحياء

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2015

الملخص الإنجليزي

Seventy one S.

aureus isolates were included in this study, of which Fifty five (77.5%) were MRSA.

67.3% of MRSA were hospital associated (HA-MRSA) while CA-MRSA were represented 32.7%.

Among MRSA, forty five isolates were resistant to erythromycin.

The presence of inducible clindamycin resistance was confirmed by the D-test for forty three (95.5%) erythromycin resistant MRSA.

Thirty three (76.7%) discordant exhibited the iMLSB phenotype, two (4.7%) the MSB and eight (18.6%) the cMLSB phenotypes.

Induction of clindamycin resistance was 1.6 times greater in CA-MRSA than in HA-MRSA (p = 0.014).

Significant prevalence was found for ermA and ermC among HA-MRSA and CAMRSA, respectively.

This is the first study in which the prevalence rate of iMLSB phenotypes in Jordan with genotypic surveillance was estimated with reinforcement on the role of erm genes in incidence of MLSB phenotypes.

Therefore, a continuous surveillance of MLSB resistance in MRSA (both community and hospitals) is of great importance before prescription of clindamycin MRSA treatment.

التخصصات الرئيسية

الأحياء

الموضوعات

• علم المناعة
• الأردن

عدد الصفحات

39

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-656398