Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals
المؤلفون المشاركون
al-Jamal, Basyuni
al-Karsh, Muhammad
Abaserie, Marwah
al-Sadani, Muhammad
المصدر
Journal of the Medical Research Institute
العدد
المجلد 27، العدد 1 (31 مارس/آذار 2006)، ص ص. 33-39، 7ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2006-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Aim : This study was undertaken to investigate the possible beneficial effects of exogenous L-arginine in ameliorating or regulating dyslipidemia and hyperglycemia induced in experimental animals.
Methods : Male Sprauge-Dawley rats were rendered dyslipidemic and hyperglycemic by intravenous injection of 20% intralipid (8.5 ml/kg b.w(.
daily for three weeks.
Plasma levels of glucose, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG) and free fatty acids (FFA) as well as liver content of TC and TG, were measured in rats that were intravenously injected with 20% intralipid for 21 days in the presence and absence of exogenous L-arginine.
Results: After intralipid administration, plasma levels of glucose, TC, LDL-C, VLDL-C, TG as well as liver content of TC and TG were significantly increased.
On the other hand, plasma levels of HDL-C were significantly decreased.
However, the intraperitoneal injection of L-arginine (500 mg / kg b.w.) for 14 days either before or after intralipid administration maintained all parameters studied at or near control values.
Conclusions : These results provide evidence of the beneficial effects of exogenously administered L-arginine in normalizing experimental dyslipidemia and hyperglycemia in rats.
These beneficial effects might be attributed to its direct NO-dependent pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Jamal, Basyuni& al-Karsh, Muhammad& Abaserie, Marwah& al-Sadani, Muhammad. 2006. Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals. Journal of the Medical Research Institute،Vol. 27, no. 1, pp.33-39.
https://search.emarefa.net/detail/BIM-65900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Jamal, Basyuni…[et al.]. Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals. Journal of the Medical Research Institute Vol. 27, no. 1 (2006), pp.33-39.
https://search.emarefa.net/detail/BIM-65900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Jamal, Basyuni& al-Karsh, Muhammad& Abaserie, Marwah& al-Sadani, Muhammad. Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals. Journal of the Medical Research Institute. 2006. Vol. 27, no. 1, pp.33-39.
https://search.emarefa.net/detail/BIM-65900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 37-39
رقم السجل
BIM-65900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر