Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals
Joint Authors
al-Jamal, Basyuni
al-Karsh, Muhammad
Abaserie, Marwah
al-Sadani, Muhammad
Source
Journal of the Medical Research Institute
Issue
Vol. 27, Issue 1 (31 Mar. 2006), pp.33-39, 7 p.
Publisher
Alexandria University Medical Research Institute
Publication Date
2006-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Aim : This study was undertaken to investigate the possible beneficial effects of exogenous L-arginine in ameliorating or regulating dyslipidemia and hyperglycemia induced in experimental animals.
Methods : Male Sprauge-Dawley rats were rendered dyslipidemic and hyperglycemic by intravenous injection of 20% intralipid (8.5 ml/kg b.w(.
daily for three weeks.
Plasma levels of glucose, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG) and free fatty acids (FFA) as well as liver content of TC and TG, were measured in rats that were intravenously injected with 20% intralipid for 21 days in the presence and absence of exogenous L-arginine.
Results: After intralipid administration, plasma levels of glucose, TC, LDL-C, VLDL-C, TG as well as liver content of TC and TG were significantly increased.
On the other hand, plasma levels of HDL-C were significantly decreased.
However, the intraperitoneal injection of L-arginine (500 mg / kg b.w.) for 14 days either before or after intralipid administration maintained all parameters studied at or near control values.
Conclusions : These results provide evidence of the beneficial effects of exogenously administered L-arginine in normalizing experimental dyslipidemia and hyperglycemia in rats.
These beneficial effects might be attributed to its direct NO-dependent pathway.
American Psychological Association (APA)
al-Jamal, Basyuni& al-Karsh, Muhammad& Abaserie, Marwah& al-Sadani, Muhammad. 2006. Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals. Journal of the Medical Research Institute،Vol. 27, no. 1, pp.33-39.
https://search.emarefa.net/detail/BIM-65900
Modern Language Association (MLA)
al-Jamal, Basyuni…[et al.]. Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals. Journal of the Medical Research Institute Vol. 27, no. 1 (2006), pp.33-39.
https://search.emarefa.net/detail/BIM-65900
American Medical Association (AMA)
al-Jamal, Basyuni& al-Karsh, Muhammad& Abaserie, Marwah& al-Sadani, Muhammad. Regulation of intralipid-induced dyslipidemia- hyperglycemia by exogenous L-arginine in experimental animals. Journal of the Medical Research Institute. 2006. Vol. 27, no. 1, pp.33-39.
https://search.emarefa.net/detail/BIM-65900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 37-39
Record ID
BIM-65900