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Improving the production of unsaturated fatty acid esters and fl avonoids from date palm pollen and their effects as anti-breast-cancer and antiviral agents : an in-vitro study
المؤلفون المشاركون
Ghanimah, Qadri Z.
Ghanim, Hasan Z.
Fadil, Muhammad
Ramadan, Manal M.
المصدر
Journal of the Arab Society for Medical Research
العدد
المجلد 10، العدد 2 (31 ديسمبر/كانون الأول 2015)، ص ص. 47-55، 9ص.
الناشر
تاريخ النشر
2015-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
- حبوب اللقاح
- الأمراض الفيروسية
- السرطان(مرض)
- العلاج الكيميائي
- الأدوية
- المواد المضادة للفيروسات
- الثدي
- مضادات الأكسدة
- كروماتوغرافيا الغاز
الملخص EN
Background / aim Pollens from different plants contain unsaturated fatty acid esters (USFAEs) and fl avonoids that play a very important role as bioactive compounds.
Therefore, the present study was designed to improve the production of volatile USFAEs and fl avonoids from date palm pollen (DPP) in a culture of Trichoderma koningii and test its activities as an anti-breast-cancer and antiviral agent.
Materials and methods The volatile esters of fermented and nonfermented date palm pollens (FDPPs) were identifi ed using gas chromatographic–mass spectrometric (GC-MS) analysis.
Antioxidant activities were determined using three different methods: the 2,2′-diphenyl-1-picrylhydrazyl (DPPH) assay, the ferric reducing antioxidant power assay, and the 2,2-azinobis(3-ethyl-benzothiazoline-6- sulfonic acid) (ABTS) assay.
Polyphenols (phenolics and fl avonoids) were also determined.
Anti-breast-cancer and antiviral activities were determined using the 3-(4,5-dimethyl-2- thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay.
Results GC–MS analysis showed an improvement in the level of USFAE in FDPP (47.99%) almost double that of the DPP results (24.11%) extract concentration.
Flavonoids content of the FDPP extract (93.4 ± 6.3 mg/ml) was higher than that obtained by the DPP extract (45.4 ± 2.1 mg/ml), which was more than double the value.
Antioxidant activity of the FDPP extract increased 3.16, 3.42, and 2.14 times that of the DPP extract as determined by the ABTS, ferric reducing antioxidant power (FRAP), and DPPH assays, respectively.
The extract of FDPP showed strong anticancer activity against the MCF-7 cell line (IC50: 9.52 μg/ml) compared with the DPP extract (IC50: 96.22 μg/ml).
Also, the FDPP extract had strong antiviral activity (CC50: 16.5 μg/ml) compared with DPP (CC50 : 38.8 μg/ml).
This is the fi rst report in which the FDPP extract is used in biological studies as anti-breast-cancer and antiviral agents.
Conclusion Fermentation of DPP by T.
koningii improves many bioactive volatile USFAE and fl avonoid contents ; these have anti-breast-cancer and antiviral activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramadan, Manal M.& Ghanim, Hasan Z.& Ghanimah, Qadri Z.& Fadil, Muhammad. 2015. Improving the production of unsaturated fatty acid esters and fl avonoids from date palm pollen and their effects as anti-breast-cancer and antiviral agents : an in-vitro study. Journal of the Arab Society for Medical Research،Vol. 10, no. 2, pp.47-55.
https://search.emarefa.net/detail/BIM-668133
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghanimah, Qadri Z.…[et al.]. Improving the production of unsaturated fatty acid esters and fl avonoids from date palm pollen and their effects as anti-breast-cancer and antiviral agents : an in-vitro study. Journal of the Arab Society for Medical Research Vol. 10, no. 2 (Dec. 2015), pp.47-55.
https://search.emarefa.net/detail/BIM-668133
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramadan, Manal M.& Ghanim, Hasan Z.& Ghanimah, Qadri Z.& Fadil, Muhammad. Improving the production of unsaturated fatty acid esters and fl avonoids from date palm pollen and their effects as anti-breast-cancer and antiviral agents : an in-vitro study. Journal of the Arab Society for Medical Research. 2015. Vol. 10, no. 2, pp.47-55.
https://search.emarefa.net/detail/BIM-668133
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 54-55
رقم السجل
BIM-668133
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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