Cd117 expression and serum cd117 in acute non lymphoid leukemia ,
المؤلفون المشاركون
Ghazzali, Taghrid
Kamel, Azzah M.
Khalaf, Muhammad R.
Jalal, Sharif Hilmi
al-Sharqawi, Nahla M.
Ghalib, Fayiq M.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 14، العدد 3 (30 سبتمبر/أيلول 2002)، ص ص. 243-249، 7ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2002-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective : the c-kit proto-oncogene encodes a 145 KDa tyrosine kinase transmembrane receptor that binds stem cell factor (SCF).
The c-kit has been classified as CD117 and the monoclonal antibody is claimed to be useful in immunophenotyping of acute leukemia.
Many studies stated that c-kit is a reliable and specific marker to detect leukemic cells committed to the myeloid lineage regardless of the French-American British (FAB) subtype.
Soluble c-kit (sc-kit, kits, s-kit) is produced by proteolytic cleavage of the cell surface receptor.
Patients And Methods : in this work, detailed phenotyp-ing and CD117 surface expression were performed on 60 patients with acute myeloid leukemia; 56 newly diagnosed, 2 relapsing AML and 2 biphenotypic leukemia (BAL).
The cases comprised 35 males and 25 females with ages ranging from 4 months to 82 years.
Assay of serum CD117 was performed by ELISA on 50 of the AML cases and 15 age-and sex-matched healthy subjects as a control.
Results : surface expression of CD117 was detected in 24.1 % of AML cases.
It was detected in 27.6 % of the adults and in 20.7 % of the children.
There was a significant correlation between CD117 surface expression and CD34 expression (p = 0.001).
Concordance between CD34 and CD117 expression was encountered in 50 cases (86.2 %), both positive in 12 (20.68 %) and both negative in 38 (65.5 %).
No significant correlation was encountered between CD117 surface expression and its serum level (p = 0.823).
There was no significant correlation between CD117 and FAB subtypes.
Conclusion : CD117 / CD34 expression and / or sCD117 may be used for detection and follow up of patients of MRD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamel, Azzah M.& al-Sharqawi, Nahla M.& Khalaf, Muhammad R.& Jalal, Sharif Hilmi& Ghalib, Fayiq M.& Ghazzali, Taghrid. 2002. Cd117 expression and serum cd117 in acute non lymphoid leukemia ,. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 3, pp.243-249.
https://search.emarefa.net/detail/BIM-67488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghazzali, Taghrid…[et al.]. Cd117 expression and serum cd117 in acute non lymphoid leukemia ,. Journal of the Egyptian National Cancer Institute Vol. 14, no. 3 (Sep. 2002), pp.243-249.
https://search.emarefa.net/detail/BIM-67488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamel, Azzah M.& al-Sharqawi, Nahla M.& Khalaf, Muhammad R.& Jalal, Sharif Hilmi& Ghalib, Fayiq M.& Ghazzali, Taghrid. Cd117 expression and serum cd117 in acute non lymphoid leukemia ,. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 3, pp.243-249.
https://search.emarefa.net/detail/BIM-67488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
includes bibliographical references : p. 248-249
رقم السجل
BIM-67488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر