Cd117 expression and serum cd117 in acute non lymphoid leukemia ,
Joint Authors
Ghazzali, Taghrid
Kamel, Azzah M.
Khalaf, Muhammad R.
Jalal, Sharif Hilmi
al-Sharqawi, Nahla M.
Ghalib, Fayiq M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 14, Issue 3 (30 Sep. 2002), pp.243-249, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2002-09-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective : the c-kit proto-oncogene encodes a 145 KDa tyrosine kinase transmembrane receptor that binds stem cell factor (SCF).
The c-kit has been classified as CD117 and the monoclonal antibody is claimed to be useful in immunophenotyping of acute leukemia.
Many studies stated that c-kit is a reliable and specific marker to detect leukemic cells committed to the myeloid lineage regardless of the French-American British (FAB) subtype.
Soluble c-kit (sc-kit, kits, s-kit) is produced by proteolytic cleavage of the cell surface receptor.
Patients And Methods : in this work, detailed phenotyp-ing and CD117 surface expression were performed on 60 patients with acute myeloid leukemia; 56 newly diagnosed, 2 relapsing AML and 2 biphenotypic leukemia (BAL).
The cases comprised 35 males and 25 females with ages ranging from 4 months to 82 years.
Assay of serum CD117 was performed by ELISA on 50 of the AML cases and 15 age-and sex-matched healthy subjects as a control.
Results : surface expression of CD117 was detected in 24.1 % of AML cases.
It was detected in 27.6 % of the adults and in 20.7 % of the children.
There was a significant correlation between CD117 surface expression and CD34 expression (p = 0.001).
Concordance between CD34 and CD117 expression was encountered in 50 cases (86.2 %), both positive in 12 (20.68 %) and both negative in 38 (65.5 %).
No significant correlation was encountered between CD117 surface expression and its serum level (p = 0.823).
There was no significant correlation between CD117 and FAB subtypes.
Conclusion : CD117 / CD34 expression and / or sCD117 may be used for detection and follow up of patients of MRD.
American Psychological Association (APA)
Kamel, Azzah M.& al-Sharqawi, Nahla M.& Khalaf, Muhammad R.& Jalal, Sharif Hilmi& Ghalib, Fayiq M.& Ghazzali, Taghrid. 2002. Cd117 expression and serum cd117 in acute non lymphoid leukemia ,. Journal of the Egyptian National Cancer Institute،Vol. 14, no. 3, pp.243-249.
https://search.emarefa.net/detail/BIM-67488
Modern Language Association (MLA)
Ghazzali, Taghrid…[et al.]. Cd117 expression and serum cd117 in acute non lymphoid leukemia ,. Journal of the Egyptian National Cancer Institute Vol. 14, no. 3 (Sep. 2002), pp.243-249.
https://search.emarefa.net/detail/BIM-67488
American Medical Association (AMA)
Kamel, Azzah M.& al-Sharqawi, Nahla M.& Khalaf, Muhammad R.& Jalal, Sharif Hilmi& Ghalib, Fayiq M.& Ghazzali, Taghrid. Cd117 expression and serum cd117 in acute non lymphoid leukemia ,. Journal of the Egyptian National Cancer Institute. 2002. Vol. 14, no. 3, pp.243-249.
https://search.emarefa.net/detail/BIM-67488
Data Type
Journal Articles
Language
English
Notes
includes bibliographical references : p. 248-249
Record ID
BIM-67488