Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice
المؤلفون المشاركون
al-Dahmash, Badr Abd Allah
al-Najjar, Dua Muhammad
Ibrahim, Khalid al-Fiqqi
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 23، العدد 2 (31 مارس/آذار 2016)، ص ص. 311-317، 7ص.
الناشر
تاريخ النشر
2016-03-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Diabetes mellitus is one of the major health problems.
This study was designed to investigate the effect of biotin to regulate blood glucose level, reduced toxicity and oxidative stress in liver of diabetic mice STZ-induced type 1.
Male mice were divided into three groups, the first one served as the control group, the second and the third groups received single ip dose of 150 mg/kg of STZ, the second group served as the untreated diabetic group, the third group received daily oral dose of 15 mg/kg of biotin, livers and liver index showed insignificant difference among groups.
Blood glucose level showed a significant decrease in treated diabetic mice compared to untreated diabetic mice.
Biochemical analysis showed a significant decrease in liver enzymes AST and ALT compared to the control group.
Histopathological examination showed severe changes in untreated diabetic liver tissue manifested by dilated portal vein, leukocytic infiltration, fatty degeneration and moderate to severe histopathological score, whereas, treated diabetic mice with biotin showed reduction in hepatotoxicity represented by appearance of relative healthy hepatocytes and normal histopathological score.
Immunohistochemistry of acrolein showed intense immunoreactions in liver section of untreated diabetic mice and faint immunoreactions in treated diabetic mice with biotin as evidence to oxidative stress reduction
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Dahmash, Badr Abd Allah& al-Najjar, Dua Muhammad& Ibrahim, Khalid al-Fiqqi. 2016. Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice. Saudi Journal of Biological Sciences،Vol. 23, no. 2, pp.311-317.
https://search.emarefa.net/detail/BIM-675006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Dahmash, Badr Abd Allah…[et al.]. Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice. Saudi Journal of Biological Sciences Vol. 23, no. 2 (2016), pp.311-317.
https://search.emarefa.net/detail/BIM-675006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Dahmash, Badr Abd Allah& al-Najjar, Dua Muhammad& Ibrahim, Khalid al-Fiqqi. Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 2, pp.311-317.
https://search.emarefa.net/detail/BIM-675006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 316-317
رقم السجل
BIM-675006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر