Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice
Joint Authors
al-Dahmash, Badr Abd Allah
al-Najjar, Dua Muhammad
Ibrahim, Khalid al-Fiqqi
Source
Saudi Journal of Biological Sciences
Issue
Vol. 23, Issue 2 (31 Mar. 2016), pp.311-317, 7 p.
Publisher
Publication Date
2016-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Diabetes mellitus is one of the major health problems.
This study was designed to investigate the effect of biotin to regulate blood glucose level, reduced toxicity and oxidative stress in liver of diabetic mice STZ-induced type 1.
Male mice were divided into three groups, the first one served as the control group, the second and the third groups received single ip dose of 150 mg/kg of STZ, the second group served as the untreated diabetic group, the third group received daily oral dose of 15 mg/kg of biotin, livers and liver index showed insignificant difference among groups.
Blood glucose level showed a significant decrease in treated diabetic mice compared to untreated diabetic mice.
Biochemical analysis showed a significant decrease in liver enzymes AST and ALT compared to the control group.
Histopathological examination showed severe changes in untreated diabetic liver tissue manifested by dilated portal vein, leukocytic infiltration, fatty degeneration and moderate to severe histopathological score, whereas, treated diabetic mice with biotin showed reduction in hepatotoxicity represented by appearance of relative healthy hepatocytes and normal histopathological score.
Immunohistochemistry of acrolein showed intense immunoreactions in liver section of untreated diabetic mice and faint immunoreactions in treated diabetic mice with biotin as evidence to oxidative stress reduction
American Psychological Association (APA)
al-Dahmash, Badr Abd Allah& al-Najjar, Dua Muhammad& Ibrahim, Khalid al-Fiqqi. 2016. Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice. Saudi Journal of Biological Sciences،Vol. 23, no. 2, pp.311-317.
https://search.emarefa.net/detail/BIM-675006
Modern Language Association (MLA)
al-Dahmash, Badr Abd Allah…[et al.]. Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice. Saudi Journal of Biological Sciences Vol. 23, no. 2 (2016), pp.311-317.
https://search.emarefa.net/detail/BIM-675006
American Medical Association (AMA)
al-Dahmash, Badr Abd Allah& al-Najjar, Dua Muhammad& Ibrahim, Khalid al-Fiqqi. Attenuation of hepatotoxicity and oxidative stress in diabetes STZ-induced type 1 by biotin in swiss albino mice. Saudi Journal of Biological Sciences. 2016. Vol. 23, no. 2, pp.311-317.
https://search.emarefa.net/detail/BIM-675006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 316-317
Record ID
BIM-675006