Detection of TET2, KRAS and CBL variants by next generation sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML
المؤلفون المشاركون
Akar, Nejat
Oner, Deniz Aslar
Bahce, Muhterem
Kurekci, Imin
Akin, Dilara Fatimah
Mumcuoglu, Mine
Ezer, Ustun
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 17، العدد 2 (30 إبريل/نيسان 2016)، ص ص. 209-215، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2016-04-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder in terms of cytogenetic and molecular aberrations.
Ten-Eleven-Translocation 2 (TET2), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Casitas B-cell lymphoma (CBL) have an important role pathogenesis of acute myeloid leukemia (AML) and their activated mutations confer proliferative and survival signals.
Aim: In this study, we aimed to find possible genetic markers for molecular analysis in childhood AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing (NGS) analysis.
In addition, association between found variants and mutations of Januse Kinase-2 (JAK2) and Fms-Related Tyrosine Kinase (FLT3) were analyzed which are important prognostic risk factors for AML.
Methods: Eight patients who were diagnosed with pediatric AML at Losante Pediatric Hematology– Oncology Hospital were included to the study.
Hot-spot exons of TET2, KRAS and CBL genes were screened using the NGS method.
Furthermore, FLT3-Internal Tandem Duplicate (FLT3-ITD) and JAK2-V617F were analyzed by Real Time Polymerase chain Reaction (Real Time-PCR).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akin, Dilara Fatimah& Oner, Deniz Aslar& Mumcuoglu, Mine& Ezer, Ustun& Bahce, Muhterem& Kurekci, Imin…[et al.]. 2016. Detection of TET2, KRAS and CBL variants by next generation sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML. The Egyptian Journal of Medical Human Genetics،Vol. 17, no. 2, pp.209-215.
https://search.emarefa.net/detail/BIM-679318
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akin, Dilara Fatimah…[et al.]. Detection of TET2, KRAS and CBL variants by next generation sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML. The Egyptian Journal of Medical Human Genetics Vol. 17, no. 2 (Apr. 2016), pp.209-215.
https://search.emarefa.net/detail/BIM-679318
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akin, Dilara Fatimah& Oner, Deniz Aslar& Mumcuoglu, Mine& Ezer, Ustun& Bahce, Muhterem& Kurekci, Imin…[et al.]. Detection of TET2, KRAS and CBL variants by next generation sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML. The Egyptian Journal of Medical Human Genetics. 2016. Vol. 17, no. 2, pp.209-215.
https://search.emarefa.net/detail/BIM-679318
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 215
رقم السجل
BIM-679318
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر