Association of serum fetuin-A and parameters of insulin resistance in type 2 diabetic patients

الملخص EN

Background : Fetuin-A (?2-Hereman Schmid glycoprotein), (AHSG) is a59 KDa multifunctional hepatic secretory protein that can inhibit insulin receptor autophosphorylation and subsequent downstream insulin signaling in vitro.

Aim: Study of human fetuin-A and its possible role in insulin resistance (IR) observed in type 2 Diabetes mellitus (DM) patients.

Subjects and Methods: Thirty five subjects were divided into two groups : A patient group included 20 patients with type 2 diabetes mellitus and a control group included 15 healthy volunteers.

Detailed history taking, clinical examination, body mass index (BMI) calculation and laboratory investigations included evaluation of serum levels of fetuin-A, tumour necrosis factor-? (TNF-?), leptin, insulin, C-peptide, fasting (FSG) and postprandial serum glucose (PPG), glycated haemoglobin (HbA1C), lipid pattern and high sensitive C.reactive protein (hs -CRP) were done.

Homeostasis model assessment of insulin resistance (HOMA-IR), insulin / glucose and C-peptide/glucose ratios were estimated.

Results : Serum fetuin-A was significantly higher in type 2 DM patients than in the control group.

A significant positive correlation was found between serum fetuin-A and serum levels of insulin, HOMA-IR, C-peptide, C-peptide / glucose ratio, insulin / glucose ratio, Leptin, TNF-?, BMI, LDLC and hs-CRP.

Conclusions : High serum fetuin-A has a strong association with IR in type 2 diabetic patients thus raising the possibility that fetuin-A could be a potential therapeutic target for treatment of type 2 diabetes.

Future studies with longitudinal cardiovascular outcomes are needed to establish the possibility of using fetuin-A as a predictor of cardiovascular events in diabetic patients.