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Association of serum fetuin-A and parameters of insulin resistance in type 2 diabetic patients
Joint Authors
Magour, Jihan M.
Abduh, Azzah S.
Mahmud, Manal M.
Source
Journal of the Medical Research Institute
Issue
Vol. 27, Issue 3 (30 Sep. 2006), pp.191-196, 6 p.
Publisher
Alexandria University Medical Research Institute
Publication Date
2006-09-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Fetuin-A (?2-Hereman Schmid glycoprotein), (AHSG) is a59 KDa multifunctional hepatic secretory protein that can inhibit insulin receptor autophosphorylation and subsequent downstream insulin signaling in vitro.
Aim: Study of human fetuin-A and its possible role in insulin resistance (IR) observed in type 2 Diabetes mellitus (DM) patients.
Subjects and Methods: Thirty five subjects were divided into two groups : A patient group included 20 patients with type 2 diabetes mellitus and a control group included 15 healthy volunteers.
Detailed history taking, clinical examination, body mass index (BMI) calculation and laboratory investigations included evaluation of serum levels of fetuin-A, tumour necrosis factor-? (TNF-?), leptin, insulin, C-peptide, fasting (FSG) and postprandial serum glucose (PPG), glycated haemoglobin (HbA1C), lipid pattern and high sensitive C.reactive protein (hs -CRP) were done.
Homeostasis model assessment of insulin resistance (HOMA-IR), insulin / glucose and C-peptide/glucose ratios were estimated.
Results : Serum fetuin-A was significantly higher in type 2 DM patients than in the control group.
A significant positive correlation was found between serum fetuin-A and serum levels of insulin, HOMA-IR, C-peptide, C-peptide / glucose ratio, insulin / glucose ratio, Leptin, TNF-?, BMI, LDLC and hs-CRP.
Conclusions : High serum fetuin-A has a strong association with IR in type 2 diabetic patients thus raising the possibility that fetuin-A could be a potential therapeutic target for treatment of type 2 diabetes.
Future studies with longitudinal cardiovascular outcomes are needed to establish the possibility of using fetuin-A as a predictor of cardiovascular events in diabetic patients.
American Psychological Association (APA)
Magour, Jihan M.& Abduh, Azzah S.& Mahmud, Manal M.. 2006. Association of serum fetuin-A and parameters of insulin resistance in type 2 diabetic patients. Journal of the Medical Research Institute،Vol. 27, no. 3, pp.191-196.
https://search.emarefa.net/detail/BIM-68160
Modern Language Association (MLA)
Magour, Jihan M.…[et al.]. Association of serum fetuin-A and parameters of insulin resistance in type 2 diabetic patients. Journal of the Medical Research Institute Vol. 27, no. 3 (2006), pp.191-196.
https://search.emarefa.net/detail/BIM-68160
American Medical Association (AMA)
Magour, Jihan M.& Abduh, Azzah S.& Mahmud, Manal M.. Association of serum fetuin-A and parameters of insulin resistance in type 2 diabetic patients. Journal of the Medical Research Institute. 2006. Vol. 27, no. 3, pp.191-196.
https://search.emarefa.net/detail/BIM-68160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 194-196
Record ID
BIM-68160