Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study
المؤلفون المشاركون
al-Khafaji, Khitam R.
al-Atrushi, Sazan A. Mirza
Abd al-Ghafur, Kifah H.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 58، العدد 1 (31 مارس/آذار 2016)، ص ص. 58-62، 5ص.
الناشر
تاريخ النشر
2016-03-31
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background : Colorectal Adenocarcinoma contributes one of the most common malignancies and the second leading cause of death from cancer in the western world.
Epidermal growth factor receptor (EGFR) belongs to a family (ErbB-tyrosine receptors), EGFR plays an important role in the pathogenesis of colorectal cancer.
Objectives : to evaluate the immunohistochemical expression of epidermal growth factor receptors (EGFR) in colorectal adenocarcinoma and to correlate this expression with different clinicopathological parameters.
Pateints and method : In this study clinicopathological parameters of twenty five colorectal adenocarcinoma cases diagnosed in private pathology laboratories in Baghdad /Iraq from November 2012 to September 2013 were respectively evaluated in terms of age, gender, pathological diagnosis including; tumor location, lymph node status.
EGFR expression was investigated immunohistochemically.
Results : twenty five colorectal cancer patients were included in this study with median age 54.5, range from (28-81)years, 15 cases (60%) were female and 10 (40%) cases were male.
Tumor size range from 3-10 cm with mean 6.5 cm, 10 (40%) cases were from rectum, 7 (28%) from the right side colon & 8 (32%) cases were from from left side colon.
Twenty three (92%) cases were moderately differentiated, and two (8%) cases were poorly differentiated, five (20%) cases were T1, 10 (40%) cases were T2, 5 (20%) cases were each T3 & T4 respectively.
3 (12%) cases were N1, 7 (28%) cases were N2, and fifteen (60%) cases have no lymph node involvement.
Three (12%) cases with distant metastasis.
Eighteen (72%) cases of colorectal adenocarcinoma demonstrate EGFR reactivity in > 1% of the tumor cells.
No significant statistical correlation was noticed between EGFR expression and each of age, gender, site of the tumor and grade of tumor (P value > 0.05).
A significant statistical correlation was noted between EGFR expression and local tumor invasion (T) and lymph node involvement (p value <0.05).
Conclusion : Epidermal growth factor receptor plays an important role in colorectal adenocarcinoma oncogenesis.
EGFR expression appears to have a value as a prognostic biomarker, since it’s expression by the tumor cells is significantly correlated to lymph node involvement and tumor local invasion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Ghafur, Kifah H.& al-Khafaji, Khitam R.& al-Atrushi, Sazan A. Mirza. 2016. Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study. Journal of the Faculty of Medicine Baghdad،Vol. 58, no. 1, pp.58-62.
https://search.emarefa.net/detail/BIM-685268
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Ghafur, Kifah H.…[et al.]. Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study. Journal of the Faculty of Medicine Baghdad Vol. 58, no. 1 (2016), pp.58-62.
https://search.emarefa.net/detail/BIM-685268
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Ghafur, Kifah H.& al-Khafaji, Khitam R.& al-Atrushi, Sazan A. Mirza. Immunohistochemical expression of epidermal growth factor receptor in human colorectal adenocarcinoma : a clinicopathological study. Journal of the Faculty of Medicine Baghdad. 2016. Vol. 58, no. 1, pp.58-62.
https://search.emarefa.net/detail/BIM-685268
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 61-62
رقم السجل
BIM-685268
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر